Results 61 to 70 of about 1,076,507 (302)

A simulated investigation on the machining instability and dynamic surface generation [PDF]

open access: yes, 2005
In this paper, the authors propose the generic concept of machining instability based on the analysis of all kinds of machining instable behaviors and their features.
Altintas   +13 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Effect of cutting parameters on the dimensional accuracy and surface finish in the hard turning of MDN250 steel with cubic boron nitride tool, for developing a knowledged base expert system

open access: yesInternational Journal of Mechanical and Materials Engineering, 2019
In the machining operations, final surface finish and dimensional accuracy are the most specified customer requirements. Hard turning machining operation using cubic boron nitride tool as an alternative of grinding process is a type of turning operation ...
Sasan Yousefi, Mehdi Zohoor
doaj   +1 more source

The efficiency of combined machinings [PDF]

open access: yes, 2012
This paper analyses the efficiency of the finish process applied in machining of hard surfaces, completed by grinding, hard turning and also by the combination of these two procedures, on the basis of time ...
Deszpoth, I., Gyáni, K., Kundrák, J.
core  

Fast Witness Extraction Using a Decision Oracle

open access: yes, 2014
The gist of many (NP-)hard combinatorial problems is to decide whether a universe of $n$ elements contains a witness consisting of $k$ elements that match some prescribed pattern.
A. Hassidim   +6 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

DETERMINATION OF OPTIMAL CUTTING CONDITIONS FOR HIGH-SPEED CENTERLESS TURNING OF ALLOY STEEL BRAND 42CRMO4 AT OJSC «BSW – MANAGEMENT COMPANY OF HOLDING «BMC»

open access: yesЛитьë и металлургия, 2018
The successful promotion of the product nowadays the manufacturer must meet all the strict requirements of the consumer in the quality of the products. At OJSC «BSW – Management Company of Holding «BMC» the centerless turning unit was put into operation,
O. Filonchik
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Investigation of the relationship between cutting force and cutting tool wear with technological parameters when turning hardening without cooling SKD11 steel

open access: yesTạp chí Khoa học và Công nghệ, 2023
This paper presents the survey results of the relationship between the value of cutting force and the tool flank wear with the cutting parameters in dry turning SKD11 steel with a hardness above 54HRC.
Hoàng Thị Diệu   +2 more
doaj  

Using Intelligent Technique Rbfnn for Prediction Recognition of Tool Wear in Hard Turning

open access: yesDiyala Journal of Engineering Sciences, 2013
Hard turning technology has been gaining acceptance in many industries throughout the last 2decades. The trend today is to replace the slow and cost-intensive grinding process with finish hard turning in many industrial applications such as bearings ...
Akeel Ali Wannas
doaj   +1 more source

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