Results 71 to 80 of about 1,076,507 (302)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
MATEC Web of Conferences, 2018 This article deals with impact of cutting conditions when hard turning of shaped-complex surfaces which are concentration origin of cracks especially in the area of notches.
Holubjak Jozef +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Hard Turning of Bearing Raceway
, 2008 Application of ceramic inserts in machining of large diameter ball bearing raceway surface, previously hardened (2 mm in depth on 56 +3 HRc), fulfils our expectances in bearing ring productivity increase. This finishing procedure is satisfactory in achieving demanded raceway quality and ensure machining time reduction. Quality is achieved even the hard
Samardžić, Ivan, Stoić, Antun
openaire +3 more sources
Residual Stresses in Machining of AISI 52100 Steel under Dry and Cryogenic Conditions: A Brief Summary [PDF]
, 2014 17th Conference on Material Forming (ESAFORM) - FinlandResidual stress is one of the most important surface integrity parameter that can significantly affect the service performance of a mechanical component, such as: contact fatigue, corrosion ...
BATISTA, Antonio +3 more
core +4 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Turning Hard Problems on Their Heads [PDF]
Phenomenology and the Cognitive Sciences, 2006 Much of the difficulty in assessing theories of consciousness stems from their advo- cates not supplying adequate or convincing characterisations of the phenomenon (or data) they hope to explain. Yet, to make any reasonable assessment this is precisely what is required, for it is not as if our 'pre-theoretical' intuitions are philosophically innocent ...
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Journal of Mechanical Engineering and Sciences, 2020 The machined surface quality and dimensional accuracy obtained during hard turning is prominently gets affected due to tool wear and cutting tool vibrations.
Nitin Ambhore +2 more
doaj +1 more source