Results 131 to 140 of about 92,483 (291)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Multi-Hazard Line Hardening with Equity Considerations: A Multi-Objective Optimization Framework

Processes
Climate change has increased the frequency and severity of extreme weather events such as wildfires, storms, high winds, and floods. Overhead lines are particularly vulnerable to these hazards, prompting utilities to consider reinforcement solutions through undergrounding overhead lines or structural hardening.
Ahmed Daeli, Salman Mohagheghi
openaire   +1 more source

On the mathematical foundation of a decoupled directional distortional hardening model for metal plasticity in the framework of rational thermodynamics

Continuum Mechanics and Thermodynamics
This study proposes a modification to the yield condition that addresses the mathematical constraints inherent in the Directional Distortional Hardening models developed by Feigenbaum and Dafalias. The modified model resolves both the mathematical inconsistency found in the complete model and the limitations of the r-model.
Rahman, Md Mahmudur, Pathik, Md Mahmudul Hasan, Islam, Nazrul   +2 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Novel Layout-Circuit Co-Design Framework for Radiation Hardening in Nanoscale Technology

2025 IEEE Nordic Circuits and Systems Conference (NorCAS)
Electronic components in space are vulnerable to radiation-induced Single-Event Effects (SEEs). This work proposes a mitigation methodology combining layout- and circuit-level analysis with targeted hardening. First, radiation induced charge deposition through the device stack is characterized and converted into equivalent transient current pulses ...
Cui, Aobo, Vacca, Eleonora, Sterpone, Luca, Azimi, Sarah   +3 more
openaire   +2 more sources

A method to represent the strain hardening effect in the hyper-elastic model within a fully Eulerian framework

Journal of Computational Physics
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Wanli Wang, Stefan Adami, Nikolaus A. Adams   +2 more
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

NeuberNet: a neural operator solving elastic-plastic partial differential equations at V-notches from low-fidelity elastic simulations

Communications Engineering
Stress concentrations at geometric irregularities such as reentrant corners make it challenging to efficiently simulate localized plastic deformation in engineering materials.
Tommaso Grossi, Marco Beghini, Matteo Benedetti   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source