Results 121 to 130 of about 5,135,844 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Ratcheting Assessment of Medium Carbon and Austenitic Steel Alloys at Elevated Temperatures

Journal of Manufacturing and Materials Processing
The present study intends to evaluate the ratcheting of ER9 wheel medium carbon steel and austenitic steel samples at room and elevated temperatures subjected to uniaxial loading cycles through the use of the Ahmadzadeh–Varvani (A–V) kinematic hardening ...
Petar Jevtic, Ahmad Varvani-Farahani
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Zero-Day Hunter: A Multi-Layered Machine Learning Framework for Real-Time Detection and Mitigation of Zero-Day Cyber Attacks

ABUAD Journal of Engineering Research and Development
Zero-day attack takes advantage of unknown vulnerability to evade traditional signature-based detection systems. We introduced a novel multi-layered machine learning (ML) framework which we call zeroHunter. The framework integrates cross-layer detection
Anthony Kwubeghari, Nwamaka Georgenia Ezeji, Francis Amaechi Okoye   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Framework for Measuring Hardening Capabilities of an Operating System

, 2007
ME Thesis (Software Engineering)Today, computers are used in all walks of life: they are in homes, in various critical domains such as defense, education, finance, government, health care, and so on.
Agrawal, Yugma Kumar
core   +1 more source

Identification of Combined Isotropic–Kinematic Hardening Parameters from Reverse Bending Tests Using Recurrent Neural Networks

Metals
Accurate identification of constitutive parameters is essential for reliable finite element simulations of sheet metal forming processes. Conventional inverse identification techniques, such as Finite Element Model Updating (FEMU), generally require ...
Daniel J. Cruz, Rui L. Amaral, Manuel R. Barbosa, Abel D. Santos, Jose Cesar de Sa   +4 more
doaj   +1 more source

Investigation of the hardening of cement-based materials with nuclear magnetic resonance (NMR)

, 2022
S.13-33Hydrogen nuclear magnetic resonance (1H NMR) is a direct method to determine the hydrogen content and with it the water content (moisture) in solids.
Dobmann, G., Wolter, B., Pel, L.
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Characterization of mechanical behavior of pipeline steel with anisotropic effect considered

You-qi chuyun
ObjectiveWith the large-scale deployment of Carbon Capture, Utilization, and Storage (CCUS), hydrogen energy, and cryogenic oil and gas transportation technologies, long-distance pipelines are exposed to increasingly complex service conditions that ...
Lei SHI, Yi ZHANG, Yi SHUAI, Liguo ZHOU, Yiran LI, Tieyao ZHANG   +5 more
doaj   +1 more source