Results 31 to 40 of about 129,139 (258)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Virtual Sensor for On-Line Hardness Assessment in TIG Welding of Inconel 600 Alloy Thin Plates

Sensors
Maintaining high-quality welded connections is crucial in many industries. One of the challenges is assessing the mechanical properties of a joint during its production phase.
Jacek Górka, Wojciech Jamrozik, Bernard Wyględacz, Marta Kiel-Jamrozik, Batalha Gilmar Ferreira   +4 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, Volume 20, Issue 6, Page 1392-1397, June 2026.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Randomness is hard

Proceedings. Thirteenth Annual IEEE Conference on Computational Complexity (Formerly: Structure in Complexity Theory Conference) (Cat. No.98CB36247), 2000
Summary: We study the set of incompressible strings for various resource bounded versions of Kolmogorov complexity. The resource bounded versions of Kolmogorov complexity we study are polynomial time CD complexity defined by Sipser, the nondeterministic variant CND due to Buhrman and Fortnow, and the polynomial space bounded Kolmogorov complexity CS ...
Buhrman, H.M., Torenvliet, L.
openaire   +6 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Enhancement in the Hardness and Corrosion Resistance of Mild Steel Surfaces by Nickel-Chromium Addition and Rapid Cooling After Welding

Journal of Applied Science and Engineering
In a corrosive environment, it is crucial to increase the hardness and corrosion resistance of mild steel bucket excavators. Making a hard layer of nickel-chromium (NiCr) alloy by the deposition method is one of the many approaches to achieve this.
Sopiyan, Syaripuddin, Adnan Ahmad, Dwi Nanto, Sigit Dwi Yudanto, Ferry Budhi Susetyo   +5 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

THE RESEARCH TECHNIQUES FOR ANALYSIS OF MECHANICAL AND TRIBOLOGICAL PROPERTIES OF COATING-SUBSTRATE SYSTEMS [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2014
The article presents research techniques for the analysis of both mechanical and tribological properties of thin coatings applied on highly loaded machine elements.
Kinga CHRONOWSKA-PRZYWARA, Marcin KOT, Sławomir ZIMOWSKI   +2 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source