Results 111 to 120 of about 884,654 (363)
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
New Media & Society, 2019 Suicide is a leading cause of death among youth, and media depictions of suicidal behavior can be a contributing risk factor. Of interest, Instagram recently received more scholarly attention due to its large number of publicly available, explicit, and ...
F. Arendt, S. Scherr, D. Romer
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
MAY WE NOT FREQUENTLY DO GREAT HARM, RATHER THAN ANY GOOD, BY OFFICE TREATMENT OF FEMALE GENERATIVE ORGANS? [PDF]
, 1900 M. B. WARD
openalex +1 more source
Ethical Theory and Moral Practice, 2018 Many legal, social, and medical theorists and practitioners, as well as lay people, seem to be concerned with the harmfulness of discriminative practices. However, the philosophical literature on the moral wrongness of discrimination, with a few exceptions, does not focus on harm.
openaire +3 more sources
Interventions for self-harm in children and adolescents
BJ Psych Advances, 2016 Self-harm (SH; intentional self-poisoning or self-injury) is common in children and adolescents, often repeated, and strongly associated with suicide. This is an update of a broader Cochrane review on psychosocial and pharmacological treatments for SH ...
K. Hawton +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Analytical Cellular PathologyImmediately after injury, damaged cells elicit tissue regeneration, a healing process that enables optimal renewal and regrowth of injured tissues. Results obtained in a large number of experimental studies suggested that the cross talk between pericytes,
Vladislav Volarevic +3 more
doaj +1 more source
Revista de Estudios Sociales, 2017 In this article I discuss some ways of relating to human suffering that have characterized research undertakings and the practice of defending human rights in Colombia that have constituted certain types of narratives about war and political violence in ...
Juan Pablo Aranguren Romero
doaj +1 more source