Results 51 to 60 of about 884,654 (363)

High-dose naloxone formulations are not as essential as we thought

Harm Reduction Journal
Naloxone is an effective FDA-approved opioid antagonist for reversing opioid overdoses. Naloxone is available to the public and can be administered through intramuscular (IM), intravenous (IV), and intranasal spray (IN) routes.
Paige M. Lemen, Daniel P. Garrett, Erin Thompson, Megan Aho, Christina Vasquez, Ju Nyeong Park   +5 more
doaj   +1 more source

Non-binary and binary transgender youth: Comparison of mental health, self-harm, suicidality, substance use and victimization experiences

International Journal of Transgenderism, 2019
Background: Little research has compared the mental health and victimization experiences of non-binary youth depending on their sex assigned at birth (SAAB), or compared these two groups with binary transgender youth. Aims: To compare mental health, self-
K. Rimes, N. Goodship, G. Ussher, D. Baker, Elizabeth West   +4 more
semanticscholar   +1 more source

Depression and Self-Harm Risk Assessment in Online Forums [PDF]

Conference on Empirical Methods in Natural Language Processing, 2017
Users suffering from mental health conditions often turn to online resources for support, including specialized online support communities or general communities such as Twitter and Reddit. In this work, we present a framework for supporting and studying
Andrew Yates, Arman Cohan, Nazli Goharian   +2 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Sustainability of opioid agonist therapy programmes in Belarus, the Republic of Moldova, Tajikistan and Ukraine in the context of transition from Global Fund support during 2020–2023

Harm Reduction Journal
Background Most national programmes of opioid agonist therapy (OAT) in Eastern Europe and Central Asia are at a critical juncture for building their sustainability due to decreasing support from the Global Fund and other international HIV funders ...
Raminta Stuikyte, Ivan Varentsov, Naimdzhon Malikov, Sergii Dvoriak, Myroslava Filippovych, Alisher Latypov, Aleksei Kralko, Ala Iatco, Catherine Cook   +8 more
doaj   +1 more source

You just have to have other models, our DNA is different: the experiences of indigenous people who use illicit drugs and/or alcohol accessing substance use treatment

Harm Reduction Journal, 2020
Objectives In Canada, and elsewhere, indigenous peoples who use illicit drugs and/or alcohol (IPWUID/A) commonly experience vulnerability and a disproportionate burden of harm related to substance use.
Jennifer Lavalley, Shelda Kastor, Malcolm Tourangeau, Western Aboriginal Harm Reduction Society, Ashley Goodman, Thomas Kerr   +5 more
doaj   +1 more source

Violence and Care: Fanon and the Ethics of Care on Harm, Trauma, and Repair

Philosophies, 2022
According to Frantz Fanon, the psychological and social-political are deeply intertwined in the colonial context. Psychologically, the colonizers perceive the colonized as inferior and the colonized internalize this in an inferiority complex.
Maggie FitzGerald
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Managing xylazine-involved overdoses in a community harm reduction setting: lessons from Tijuana, Mexico

Harm Reduction Journal
Background Xylazine is a α2-adrenergic receptor agonist, used for sedation in veterinary contexts. Although it is increasingly found in overdose deaths across North America, the clinical management of xylazine-involved overdoses has not been extensively ...
Lilia Pacheco Bufanda, Alejando González Montoya, Brenda Torres Carrillo, Mariana Alejandra Gonzalez Tejeda, Luis A. Segovia, Alhelí Calderón-Villarreal, Joseph R. Friedman   +6 more
doaj   +1 more source

Harms of AI

SSRN Electronic Journal, 2021
Abstract This essay discusses several potential economic, political, and social costs of the current path of AI technologies. I argue that if AI continues to be deployed along its current trajectory and remains unregulated, it may produce various social, economic, and political harms. These include: damaging competition, consumer privacy,
openaire   +2 more sources