Results 81 to 90 of about 518,464 (269)

Supported discharge service versus inpatient care evaluation (SITE): a randomised controlled trial comparing effectiveness of an intensive community care service versus inpatient treatment as usual for adolescents with severe psychiatric disorders: self-harm, functional impairment, and educational and clinical outcomes [PDF]

, 2020
Dennis Ougrin, Richard Corrigall, Daniel Ståhl, Jason Poole, Toby Zundel, Mandy Wait, Victoria Slater, Paula Reavey, Sarah Byford, John Ivens, Maarten Crommelin, Daniel Hayes, Kerry Middleton, Paul Young, Eric Taylor   +14 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Abuse‐deterrent extended‐release oxycodone and risk of opioid‐related harm [PDF]

, 2021
Tapio Paljärvi, John Strang, Patrick D. Quinn, Sierra Luciano, Seena Fazel   +4 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Rural community-based participatory research with families of people who use drugs: key considerations from a multi-provincial research partnership

Harm Reduction Journal
Background North America continues to contend with an unregulated drug crisis that is impacting communities of all sizes. Community-based participatory research that meaningfully engages people who use drugs, families, and their wider communities is one ...
Holly Mathias, Elsie Duff, Petra Schulz, Sarah Auger, Antoinette Gravel-Ouellette, Teresa Lockhart, Willi McCorriston, Jenn McCrindle, Nyal Mirza, Em Pijl, Tyla Savard, Elaine Hyshka   +11 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Towards an understanding of maltreatment in football

Frontiers in Sports and Active Living
IntroductionThis study explored the understanding of maltreatment from the perspective of various personnel working in roles related to safeguarding and welfare in English professional and semi-professional football.MethodThrough a social constructivist ...
James A. Newman, James L. Rumbold
doaj   +1 more source

Successful Treatment of Severe Occipitocervical Pain from C1-C2 Osteoarthritis Using a Modified Harms Technique [PDF]

, 2016
Ara Deukmedjian, Augusto Cianciabella, Bharat Patel, Arias Deukmedjian   +3 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Effects of green manuring on chemical characteristics and microecology of tobacco-growing soil in central henan

BMC Microbiology
Objective This study explored green manuring effects on microecology, carbon/nitrogen levels, and enzyme activity in tobacco-growing soils. Methods After 30,000 kg·hm⁻² overpressure and 28 days of natural decomposition, plants (Hordeum vulgare L.
Wei Liu, Xiaolong Chen, Yuanyuan Zhao, Hongzhi Shi   +3 more
doaj   +1 more source