Results 131 to 140 of about 861,589 (345)

Disrupting and Maintaining Prohibition: Institutional and Grassroots Harm Reduction Practices in Ottawa

, 2022
Lisa Wright
openalex   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Methadone clinic staff perceptions of trauma-informed and patient-centered care: the role of individual staff characteristics

Addiction Science & Clinical Practice
Background U.S. policy intervention to increase methadone treatment accommodations during COVID did not result in national adoption of the new patient-centered treatment practices.
Beth E. Meyerson, Linnea B. Linde-Krieger, Gregory A. Carter, Allison J. Huff, Benjamin R. Brady, Richard A. Crosby, Jennifer De La Rosa, Allie Allison, Mohammad Barakat, Michael Pava, Mark Schaefer   +10 more
doaj   +1 more source

If Supply-Oriented Drug Policy is Broken, Can Harm Reduction Help Fix It?—Melding Disciplines and Methods to Advance International Drug Control Policy [PDF]

Critics of the international drug control regime contend that supply-oriented policy interventions are not just ineffective, but they also produce unintended adverse consequences. Research suggests their claims have merit.
Letizia Paoli, Victoria A. Greenfield
core  

The potential role of snus products within a tobacco harm reduction strategy [PDF]

, 2009
Anna Gilmore, John Britton, Deborah Arnott, Richard Ashcroft, M. J. Jarvis   +4 more
openalex   +1 more source

Pulverizing medication as a harm reduction and intentional drug overdose prevention strategy: Two case studies [PDF]

, 2021
Keisuke Takanobu, Daisuke Okazaki, Shinya Watanabe, Nobuyuki Mitsui, Teruaki Tanaka   +4 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effects of green manuring on chemical characteristics and microecology of tobacco-growing soil in central henan

BMC Microbiology
Objective This study explored green manuring effects on microecology, carbon/nitrogen levels, and enzyme activity in tobacco-growing soils. Methods After 30,000 kg·hm⁻² overpressure and 28 days of natural decomposition, plants (Hordeum vulgare L.
Wei Liu, Xiaolong Chen, Yuanyuan Zhao, Hongzhi Shi   +3 more
doaj   +1 more source

“Drugs are a taboo”: a qualitative and retrospective study on the role of education and harm reduction strategies associated with the use of psychoactive substances under the age of 18 [PDF]

, 2021
Gabriela Almeida Pinto da Silva, Catarina Pinto Pereira, Marta Pinto   +2 more
openalex   +1 more source