Results 111 to 120 of about 861,589 (345)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
"No" to Policy Reversal: Backsliding in Tariff Policy Can Do More Harm than Good [PDF]
In recent months, growing evidence has shown that there seems to be an apparent trend for backsliding or reversal of the government policy on tariff reduction. Why is this happening? And what is its implication?
Aldaba, Rafaelita M. +1 more
core
Britain's alcohol problem and what the UK government is (and is not) doing about it [PDF]
, 2006 Britain is currently experiencing a serious alcohol problem, as shown particularly by a steep increase in rates of liver cirrhosis mortality and by widespread alcohol-related disorder and harm among young people.
Heather, Nick
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Harm Reduction JournalBackground Overdose prevention centers (OPCs), also known as supervised injection facilities and safe consumption sites, are evidenced-based interventions for preventing overdose deaths and drug-related morbidities. The pathways to legalizing OPCs in the
Joseph G. Rosen +5 more
doaj +1 more source
Police support for harm reduction policies and practices towards people who inject drugs. Modernising drug law enforcement report 1. [PDF]
, 2013 The objective of this project, led by the International Drug Policy Consortium, with the participation of the International Security Research Department at Chatham House and the International Institute for Strategic Studies, is to collate and refine ...
Bewley-Taylor, Dave, Monaghan, Geoffrey
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Supply-side reduction policy and drug-related harm [PDF]
Large-scale seizures of cocaine, heroin and amphetamine-type substances (ATS) do not result in any reduction in overdoses on these drugs or on arrests for use and possession of these drugs, according to this report.
Don Weatherburn +4 more
core +1 more source