Results 121 to 130 of about 861,589 (345)
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Supervised Injection Facilities: Legal and Policy Reforms [PDF]
The US Centers for Disease Control and Prevention reported that more than 70 000 deaths from drug overdoses occurred in 2017, including prescription and illicit opioids, representing a 6-fold increase since 1999.
Gostin, Lawrence O. +2 more
core +1 more source
The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction [PDF]
Giuseppe Lo Sasso +5 more
openalex +1 more source
E-Cigarettes—a review of the evidence—harm versus harm reduction [PDF]
Susan Feeney +2 more
openalex +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Reverse spin bias: preliminary observations of reporting bias in medical systematic reviews
Background While conducting an umbrella review of e-cigarettes for smoking cessation, we observed that in many instances, systematic review authors reported findings favorable to the treatment, yet they declined to recommend it or recommended against it ...
Renée O’Leary +2 more
doaj +1 more source

