Results 101 to 110 of about 3,578,042 (213)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
If Supply-Oriented Drug Policy is Broken, Can Harm Reduction Help Fix It?—Melding Disciplines and Methods to Advance International Drug Control Policy [PDF]
Critics of the international drug control regime contend that supply-oriented policy interventions are not just ineffective, but they also produce unintended adverse consequences. Research suggests their claims have merit.
Victoria A. Greenfield, Letizia Paoli
core
Prison staff and harm reduction: a training manual [PDF]
, 2010 This manual is designed to assist in the process of training prison staff in harm reduction. This package will not teach you how to become a trainer, does not teach you how to conduct and deliver harm reduction nor does it contain all the information on
Purvlice, Baiba +7 more
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Defining Harm Reduction as Part of a Public Health Approach Towards Gambling
, 2019 This chapter presents the concept of harm reduction (HR), which was developed in the 1980s in response to prevention issues related to the intravenous use of psychoactive substances.
Simon, Olivier +7 more
core +1 more source
Analytical Cellular PathologyImmediately after injury, damaged cells elicit tissue regeneration, a healing process that enables optimal renewal and regrowth of injured tissues. Results obtained in a large number of experimental studies suggested that the cross talk between pericytes,
Vladislav Volarevic +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Towards harm reduction programmes with sex worker clients in South Africa [PDF]
, 2020 This report explores possible harm reduction approaches to a sex worker client intervention in the South African context. It considers the current evidence base on client interventions globally and sets out key recommendations for an effective client ...
Richter, Marlise, Huysamen, Monique
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Harm Reduction JournalBackground Overdose prevention centers (OPCs), also known as supervised injection facilities and safe consumption sites, are evidenced-based interventions for preventing overdose deaths and drug-related morbidities. The pathways to legalizing OPCs in the
Joseph G. Rosen +5 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source