Results 101 to 110 of about 225,166 (306)
Harm reduction in Europe: mapping coverage and civil society advocacy.
, 2011 The european Harm Reduction network, or euroHRn, was formed in 2009 by ten civil society organisations with a shared interest in advocating for and sharing knowledge on harm reduction within europe.
Stoicescu, Claudia, Cook, Catherine
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
, 2017 Background The perspectives of people who use drugs are critical in understanding why people choose to reduce harm in relation to drug use, what practices are considered or preferred in conceptualizations of harm reduction, and which environmental ...
A. Martin +27 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
How we understand fully the supply, demand, and harm reduction in drugs policy in Vietnam?
Since the 1990s, Vietnam has begun prioritising preventing and combating drug-related crimes (supply reduction) and rehabilitating drug users (demand reduction).
Luong, Hai Thanh
core +1 more source
Hotel of Last Resort: Enhancing User Agency in Harm Reduction Architecture
, 2020 Homeless individuals who use drugs represent some of the most vulnerable and marginalized among society. In the context of a national opioid epidemic in Canada, harm reduction strategies, which reduce the adverse consequences associated with practices or
Manoy, Kamille
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Reducing structural harm to empower youth [PDF]
, 2019 Presented at the Harm Reduction International Conference (HR19), Porto, Portugal 2019. Amidst one of the most significant public health emergencies, Vancouver Coastal Health (VCH) recognized the need to address the growing and changing needs of youth ...
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Defining Harm Reduction as Part of a Public Health Approach Towards Gambling
, 2019 This chapter presents the concept of harm reduction (HR), which was developed in the 1980s in response to prevention issues related to the intravenous use of psychoactive substances.
Simon, Olivier +7 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source