Results 91 to 100 of about 225,166 (306)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Culture, church, and collective: a qualitative study about gambling harm prevention and reduction in Aotearoa/New Zealand—a Tongan male perspective

, 2022
Background In New Zealand, Pacific people continue to be more at risk of gambling harm than the general population, despite increasing public health efforts and treatment service provisions introduced to address this social and health issue.
Bellringer, Maria E, Fairbairn-Dunlop, Peggy, Edmond S. Fehoko, Peggy Fairbairn-Dunlop, Bellringer, Maria E., Fehoko, Edmond S, Maria E. Bellringer, Fehoko, Edmond S.   +7 more
core   +1 more source

Mechanisms for reducing cigar tobacco leaf irritancy during acidic fermentation

AMB Express
This study explored the effects of an acidic fermentation environment on the quality of cigar tobacco leaves using air-cured “Dexue 1” tobacco leaves as the raw material.
Wei Liu, Yuanyuan Zhao, Tian Zhou, Mengru Bai, Jun Wang, Caining Qi, Jiayi Li, Yanqing Qin, Hongzhi Shi   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

New psychoactive substances in Eurasia: a qualitative study of people who use drugs and harm reduction services in six countries

Harm Reduction Journal, 2020
Background This study examines the use of new psychoactive substances (NPS) and the harm reduction response in six Eurasian countries: Belarus, Moldova, Serbia, Kazakhstan, Kyrgyzstan, and Georgia.
Eliza Kurcevič, Rick Lines
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Smoked cocaine in socially-depressed areas

, 2010
Background: The main objectives of this study are to describe the smoked cocaine user's profile in socially-depressed areas and their needs from a harm-reduction perspective, to investigate their use of smoking crack and compare the acute effects between
Pons-Prat, Montserrat, Olga Díaz, Delás, Jordi, Elena Adán, Pons Montserrat, Díaz Olga, Aguas Compaired, M. (Margarita), Adan, Elena, Adán Elena, Margarita Aguas, Diaz, Olga, Montserrat Pons, Aguas Margarita, Jordi Delas, Delas Jordi, Fuertes Ricardo, Ricardo Fuertes, Fuertes, Ricardo   +17 more
core   +1 more source

Tobacco harm reduction: the devil is in the deployment [PDF]

, 2012
First paragraph: The idea of tobacco harm reduction -- that smokers who cannot wean themselves off nicotine should be encouraged to adopt less harmful ways of consuming it -- has much to recommend it.
Hastings, Gerard, De Andrade, Marisa, Moodie, Crawford   +2 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source