Results 71 to 80 of about 3,578,042 (213)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Measuring sustainability of opioid agonist therapy programs in the context of transition from Global Fund support

Harm Reduction Journal
Background Programmatic and financial sustainability of health responses dependent on donor funding has risen as a major concern. In the HIV field in particular, it generated a number of instruments and assessments on sustainability and processes related
Raminta Stuikyte, Ivan Varentsov, Catherine Cook, Sergii Dvoriak   +3 more
doaj   +1 more source

Emerging ketamine and analogues trends in Canada’s illicit drug market between 1994 and 2025: A retrospective descriptive study of Health Canada’s Drug Analysis Service data

Emerging Trends in Drugs, Addictions, and Health
Background: Ketamine is a dissociative anesthetic well established in the Canadian illicit drug market. Recent changes in availability, mixture with other drugs, and emergence of novel analogues have raised concerns in several jurisdictions.
Melina Thibault, Sarah O’Connor, Caroline Maurice-Gelinas, Priscilla Karnabi, Justin Dyck, Marie-Line Gilbert, Thierry Lefrançois, Katherine Groison   +7 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Smoked cocaine in socially-depressed areas [PDF]

, 2010
Background: The main objectives of this study are to describe the smoked cocaine user's profile in socially-depressed areas and their needs from a harm-reduction perspective, to investigate their use of smoking crack and compare the acute effects between
Pons-Prat, Montserrat, Olga Díaz, Delás, Jordi, Elena Adán, Pons Montserrat, Díaz Olga, Aguas Compaired, M. (Margarita), Adan, Elena, Adán Elena, Margarita Aguas, Diaz, Olga, Montserrat Pons, Aguas Margarita, Jordi Delas, Delas Jordi, Fuertes Ricardo, Ricardo Fuertes, Fuertes, Ricardo   +17 more
core   +1 more source

Mechanisms for reducing cigar tobacco leaf irritancy during acidic fermentation

AMB Express
This study explored the effects of an acidic fermentation environment on the quality of cigar tobacco leaves using air-cured “Dexue 1” tobacco leaves as the raw material.
Wei Liu, Yuanyuan Zhao, Tian Zhou, Mengru Bai, Jun Wang, Caining Qi, Jiayi Li, Yanqing Qin, Hongzhi Shi   +8 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The lost decade: neglect for harm reduction funding and the health crisis among people who use drugs. [PDF]

, 2018
Harm reduction interventions for people who use drugs—such as needle and syringe programmes (NSP) and opioid substitution therapy (OST)—are cost-effective, protect against HIV and hepatitis C, and save lives. Despite the potential for these interventions
Davis, Charlotte, Cook, Catherine
core  

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source