Results 141 to 150 of about 824,404 (357)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Addiction Science & Clinical PracticeBackground U.S. policy intervention to increase methadone treatment accommodations during COVID did not result in national adoption of the new patient-centered treatment practices.
Beth E. Meyerson +10 more
doaj +1 more source
Cops, drugs and the community: establishing consultative harm reduction structures in two Western Australian locations [PDF]
, 2002 Richard Midford +4 more
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
TOBACCO HARM REDUCTION INVOLVES MORE THAN CIGARETTE HARM REDUCTION
American Journal of Public Health, 2004 I contributed to the Institute of Medicine report Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction,1 and I am writing to correct misrepresentations made about it in 2 recent articles in the Journal.2,3 The articles suggest that the report signals a rebirth of “safer cigarettes”2 and that it was primarily about cigarette harm ...
openaire +4 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Harm Reduction JournalIntroduction People who use drugs (PWUD) are at increased risk for HIV infection. HIV self-testing (HIVST) is a promising method for identifying new infections, but optimal distribution strategies remain understudied.
William H. Eger +7 more
doaj +1 more source
Drug Use, Harm Reduction, and Health Policies in Argentina: Obstacles and New Perspectives [PDF]
, 2003 Silvia Inchaurraga
openalex +1 more source