Results 61 to 70 of about 4,746,761 (313)

Having a voice and saving lives: a qualitative survey on employment impacts of people with lived experience of drug use working in harm reduction

Harm Reduction Journal, 2021
Background Ongoing legal and social discrimination, and stigmatization of people with lived experience of drug use (PWLE) continues to contribute to overdose-related deaths in Canada.
Brandi Jennifer Loretta Julien Frank Alexandra Hugh Dawn Abele Bowser Brown Carette Crichlow de Kiewit Lamp, Brandi Abele, J. Bowser, L. Brown, Julien Carette, Frank Crichlow, Alexandra de Kiewit, Hugh Lampkin, Dawn Lavand, Sean Leblanc, Alex Sherstobitoff, Rick Sproule, N. Touesnard, Karen Turner, Dean Wilson, Kelsey Van Pelt, Tamar Austin, Jade Boyd   +17 more
semanticscholar   +1 more source

Parental Licensing as Harm Reduction [PDF]

Health Care Analysis, 2020
AbstractIn this paper, I will argue that some prominent objections to parental licensing rely on dubious claims about the existence of a very stringent, if not indefeasible, right to parent, which would be violated by licensing. I claim that attaching such stringency to the right only makes sense if we make a number of idealising assumptions. Otherwise,
openaire   +4 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

ERS and tobacco harm reduction [PDF]

European Respiratory Journal, 2019
ERS supports the World Health Organization9s Framework Convention on Tobacco Control, which also provides regulation to novel products, and cannot recommend tobacco harm reduction as a population-based strategyhttp://bit.ly ...
Pisinger, C, Dagli, E, Filippidis, FT, Hedman, L, Janson, C, Loukides, S, Ravara, S, Saraiva, I, Vestbo, J, ERS Tobacco Control Committee, on behalf of the ERS   +10 more
openaire   +5 more sources

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey

Frontiers in Psychiatry, 2020
Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic.
Seyed Ramin Radfar, C. D. De Jong, A. Farhoudian, Mohsen Ebrahimi, P. Rafei, Mehrnoosh Vahidi, M. Yunesian, C. Kouimtsidis, Shalini Arunogiri, Omid Massah, A. Deylamizadeh, K. Brady, A. Busse   +12 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Smoking Harm Reduction

American Journal of Public Health, 2016
A letter to the editor is presented in response to the article "New product marketing blurs the line between nicotine replacement therapy and smokeless tobacco products," by Ganna Kostygina, Lucinda England and Pamela M. Ling along with a response from the authors.
openaire   +3 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source