Results 161 to 170 of about 5,752 (199)

Mechanisms of tremor induction by harmine

European Journal of Pharmacology, 1974
Abstract Various agents known to modify cerebral serotoninergic, dopaminergic and cholinergic function were used to investigate the possible relationship between these transmitter systems and the induction and modulation of harmine tremor. The results indicate a non-involvement of cerebral cholinergic function and a possible involvement of cerebral ...
D M, Kelly, R J, Naylor
openaire   +2 more sources

Harmine: Evaluation of Its Antileishmanial Properties in Various Vesicular Delivery Systems

Journal of Drug Targeting, 2004
Harmine, a beta-carboline amine alkaloid isolated from Peganum harmala, was tested for its antileishmanial properties both in vitro and in vivo. In vitro antileishmanial activity of harmine was encouraging and prompted us to confirm the activity in ...
Sanchaita Lala, Santu Bandyopadhyay
exaly   +2 more sources

Harmine Action in Rats with Lymphostatic Encephalopathy

Pharmacology, 2008
In rats with lymphostatic encephalopathy the duration of harmine tremor was lengthened, and the brain concentrations of harmine decreased more slowly than in sham-operated controls. The tremor began simultaneously in both rat groups at coinciding brain concentrations of harmine.
G, Back, G, Seidel
openaire   +2 more sources

Pharmacological Effects of Harmine and Its Derivatives: A Review

Archives of Pharmacal Research, 2020
Harmine is isolated from the seeds of the medicinal plant, Peganum harmala L., and has been used for thousands of years in the Middle East and China. Harmine has many pharmacological activities including anti-inflammatory, neuroprotective, antidiabetic, and antitumor activities.
Liang, Zhang, Dengchang, Li, Shenglan, Yu   +2 more
exaly   +3 more sources

An investigation of the tremorgenic actions of harmine in the rat

European Journal of Pharmacology, 1971
Abstract Antagonism of harmine tremor by drugs which interfere with adrenergic nervous function was investigated in rats. Reserpine, diethyldithiocarbamic acid and propranolol reduced the intensity of the tremor without abolishing it completely. Phenoxybenzamine, mebanazine and atropine were without effect.
B, Cox, D, Potkonjak
openaire   +2 more sources

The Harmine Group of Alkaloids

1937
Harmine and harmaline are alkaloids found in the seeds of Peganum harmala and the pharmacological actions of these alkaloids, as well as of many artifically prepared derivatives of them, have now been investigated in considerable detail. The seeds of the plant have been used therapeutically for centuries and a brief reference to this earlier history ...
openaire   +1 more source

Harmine as a substitute for 33258 Hoechst in the FPG technique

Histochemistry, 1988
We studied the effectiveness of harmine as a substitute for 33258 Hoechst in the fluorescence-plus-Giemsa technique, using Allium cepa chromosomes after 5-bromo-2'-deoxyuridine (BrdU) incorporation. Harmine showed a photosensitizing capacity which was somewhat higher than 33258 Hoechst and used half of the time established for the usual treatment.
M G, Gutiérrez-Gonzálvez, M J, Hazen, R H, Espelosín   +2 more
openaire   +2 more sources

Harmine

2007
S.J. Enna, David B. Bylund
openaire   +2 more sources

A MODEL OF HARMINE METABOLISM IN THE RAT

The Journal of Pharmacology and Experimental Therapeutics, 1970
T A, Slotkin, V, DiStefano
openaire   +2 more sources

Harmine Inhibits the Proliferation and Migration of Glioblastoma Cells via the FAK/AKT Pathway

Life Sciences, 2021
Huang Kuang, Yun-Xia Lv
exaly