Results 51 to 60 of about 1,153,298 (314)

A Fatou theorem for $F$-harmonic functions

, 2016
In this paper we study a class of functions that appear naturally in some equidistribution problems and that we call $F$-harmonic. These are functions of the universal cover of a closed and negatively curved which possess an integral representation ...
Alvarez, Sébastien
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Irreversible quantum graphs

, 2003
Irreversibility is introduced to quantum graphs by coupling the graphs to a bath of harmonic oscillators. The interaction which is linear in the harmonic oscillator amplitudes is localized at the vertices.
Breit G, Carlson R, Feshbach H, Feshbach H, Feynman R P, Killip R, Killip R Simon B, Kostrykin V, Kottos T, Kottos T, Kottos T, Kottos T, Kuchment P, Pauli W, Solomyak M, Uzy Smilansky, Van Hove L   +16 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Trimming Strategy for Mass Defects in Hemispherical Resonators Based on Multi-Harmonic Analysis

Micromachines
This study investigates the impact of etching trimming parameters on the multiple harmonics of the mass distribution in hemispherical resonators and proposes a novel 1st harmonic trimming scheme.
Yimo Chen, Fanrui Kong, Kai Zeng, Xiang Xi, Yan Shi, Dingbang Xiao, Xuezhong Wu   +6 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Harmonic Oscillators in CMOS—A Tutorial Overview

IEEE Open Journal of the Solid-State Circuits Society, 2021
The harmonic oscillator is a truly irreplaceable as well as ubiquitous analog integrated circuit. Starting from the basics of its CMOS implementation, we will discuss the phase noise of the harmonic oscillator in some detail, where the intrinsic large ...
Pietro Andreani, Andrea Bevilacqua
doaj   +1 more source

Harmonic monsters

Journal of Approximation Theory, 2003
Using a theorem of \textit{S. J. Gardiner} [Harmonic approximation (1995; Zbl 0826.31002)], the author shows that there exists a harmonic function \(h\) on a non-empty open subset \(\Omega\) of \(\mathbb{R}^d\), where \(d\geq 2\), which behaves wildly near every boundary point of \(\Omega\).
openaire   +1 more source

Harmonic Causation and Harmonic Echoes [PDF]

Nature, 1873
IN reference to the question of “Harmonic Echoes,” allow me to suggest to those who may have the opportunity of observation, how desirable it is that these echo-tones should be investigated in a manner to determine whether they are truly harmonic or not. There would be no difficulty in testing the sounds given in response to the notes of a closed organ-
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source