Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang +22 more
wiley +1 more source
Design of the RLC Filter in Cascaded Inverter System
The cascaded inverter is widely used in high-voltage large-capacity system because of the sine output and low cost. However, in some special conditions, the harmonics component of output voltage will intensify heating of the reactor and motor windings ...
WANG Shiping +4 more
doaj
Simulation and experiment of coal desulfurization model
A new coal desulfurization model of dielectric barrier discharge was built, and based on it, factors impacting on effect of desulfurization discharge, including dielectric types, dielectric thickness, gap spacing, supply voltage, power frequency were ...
XU Yunzhi +5 more
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth +8 more
wiley +1 more source
Fracture Analysis of Toughness Fracture Failure on Flexspline of Harmonic Reducers During the Service [PDF]
The reasons of the fatigue failure of flexspline are analyzed by observation analysis, observation and hardness determination of fracture morphology of microstructure.
Mu Xiaobiao, Zhang Yongqi, Gao Minyan, Yang Guoqiang, Zhang Chaolei
doaj +1 more source
On harmonic and asymptotically harmonic Finsler manifolds
In the present paper we introduce and investigate some types of harmonic Finsler manifolds and find out the interrelation between them. We give some characterizations of such spaces in terms of the Finsler mean curvature of geodesic spheres and the Finsler Laplacian of the distance function induced by the Finsler metric.
Shah, Hemangi, Taha, Ebtsam H.
openaire +2 more sources
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source

