Results 221 to 230 of about 2,541,468 (293)

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Symmetry Engineering in Heterometallic TMDC Mo_(1-x)Nb_xSe₂: A Systematic Route Toward Enhanced Nonlinear Optical Performance. [PDF]

Small
Hani SU, Alam TI, Liang K, Yang K, Ahmed S, Xu L, Yang M, Zhu Y, Tsang YH.   +8 more
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Mode-locked optomechanical frequency combs in a graphene-silica microresonator. [PDF]

Sci Adv
Zhang H, Liang YP, Tan T, Wen SD, Yu Y, An N, Liu YW, Guo YH, Gong QH, Huang YJ, Rao YJ, Xiao YF, Yang QF, Yao BC.   +13 more
europepmc   +1 more source

OpenMRF: A Modular, Vendor‐Neutral Open‐Source Framework for Magnetic Resonance Fingerprinting Using Pulseq

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Widespread adoption and methodological advancement of magnetic resonance fingerprinting (MRF) are limited by the lack of unified, reproducible implementation frameworks and fragmented open‐source tools. To address these barriers, we introduce OpenMRF—a comprehensive Pulseq‐based solution—designed to enable standardized and transferable
Tom Griesler, Jannik Stebani, Sydney Kaplan, Ivaylo Angelov, Petra Albert, Tobias Wech, Martin Blaimer, Xiang Wang, Qingping Chen, Maxim Zaitsev, Zhibo Zhu, Qi Liu, Peter Martin, Jon‐Fredrik Nielsen, Jesse I. Hamilton, Peter Nordbeck, Nicole Seiberlich, Maximilian Gram   +17 more
wiley   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Missed isochromatic cardiac pulsation in remote photoplethysmography: detection, impact, and removal. [PDF]

Biomed Opt Express
Kaur G, Lakshminarayanan V, Saini SS.
europepmc   +1 more source

Combined Effects of Thermal Cycling Aging and Reinforcement Content on the Ball‐On‐Disk Wear of Additively Manufactured Polylactic Acid Composites

Polymer Composites, EarlyView.
Thermal Aging and Tribological Tests of Additive Manufactured PLA Composites. ABSTRACT This study focuses on the additive manufacturing of pure polylactic acid (PLA) specimens and milled glass fiber (GF)‐filled PLA composites under thermal cycling aging and wear tests. Wear tracks have been analyzed via 3D optical profiling and SEM imaging.
Sinan Fidan, Satılmış Ürgün, Nevin Gamze Karsli, Taner Yilmaz, Mustafa Özgür Bora, Mehmet İskender Özsoy   +5 more
wiley   +1 more source

Non-local synchronization of continuous time crystals in a semiconductor. [PDF]

Nat Commun
Greilich A, Kopteva NE, Korenev VL, Haude PA, Kunze L, Grobecker BW, Anghel S, Betz M, Bayer M.   +8 more
europepmc   +1 more source

Stair‐Climbing Wheelchairs for Enhanced Mobility: A Comprehensive Review of Fundamental Mechanisms, Design Concepts, and Performance Analysis

Journal of Field Robotics, EarlyView.
ABSTRACT People with physical disabilities face significant mobility challenges while climbing uneven surfaces and staircases. In these circumstances, traditional wheelchairs do not provide stable, safely controlled mobility, underscoring the importance of building superior stair‐climbing wheelchairs for both medical and infrastructure purposes.
Gopisetti Manikanta, S. M. Abhinandan, Anand Reddy, G. Chandana, Divya, P. Anil Kumar, Ch. Venkata Rao, Ashish Garg, Ravi C. Soni, Jogendra Kumar, Bhargav Akkinepally   +10 more
wiley   +1 more source