Results 121 to 130 of about 1,936,197 (337)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Tackling post-harvest cereal losses in sub-Saharan Africa [PDF]

, 2013
Post-harvest loss reduction raises food availability without increasing the use of land, water and agricultural inputs. This article refers to the case of grain to show the hurdles that farmers have to clear in taking measures to reduce losses and ...
Bennett, Ben, Bernard, Marc, Hodges, Rick, Rembold, Felix   +3 more
core  

Post-Harvest Loss in Sub-Saharan Africa -- What Do Farmers Say?

, 2014
The 2007-2008 global food crisis has renewed interest in post-harvest loss, but estimates remain scarce, especially in Sub-Saharan Africa. This paper uses self-reported measures from nationally representative household surveys in Malawi, Uganda, and ...
J. Kaminski, L. Christiaensen
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Impact of Flower Harvesting on the Salt Marsh Plant \u3cem\u3eLimonium carolinianum\u3c/em\u3e [PDF]

, 2002
Because of the potentially detrimental effects of seed production on adult survivorship and growth, moderate flower harvesting may have little negative impact on population growth of long-lived perennial plants such as Limonium carolinianum (Walter ...
Baltzer, Jennifer L., Boates, J. Sherman, Hewlin, Heather L., Reekie, Edward G., Taylor, Philip D.   +4 more
core   +1 more source

Review on pre- and post-harvest management of peanuts to minimize aflatoxin contamination

, 2014
Peanut or groundnut (Arachis hypogaea L.) is cultivated in the tropical and warm temperate regions of the world. Its production reaches approximately 39.9 million metric tons per year.
A. Torres, G. Barros, S. Palacios, S. Chulze, P. Battilani   +4 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Study of temporal behaviour of meteorological drought using innovative polygon trend and scaling hypothesis methods in Kolasib district, Mizoram, India

Scientific Reports
Drought, one of the most frequent water-related disasters, puts a great deal of strain on agriculture and associated activities in all types of climates.
Bivek Chakma, G S Yurembam, Deepak Jhajharia, G T Patle, Rakesh Salam, Saurav Saha   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Characterization of Zalaria obscura Y1223 hydrolases: implications for lignocellulose conversion

AMB Express
Overconsumption of fossil fuel reserves and its adverse effects has sparked interest in the production of second-generation biofuels due to the abundance of lignocellulosic waste and potential energy crops.
Jeremy J. Boonzaier, Rodney S. Hart, Justin W. Hoff, Heinrich W. du Plessis, Riaan den Haan   +4 more
doaj   +1 more source