Results 51 to 60 of about 550,312 (276)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

DeepPricing: pricing convertible bonds based on financial time-series generative adversarial networks

open access: yesFinancial Innovation, 2022
Convertible bonds are an important segment of the corporate bond market, however, as hybrid instruments, convertible bonds are difficult to value because they depend on variables related to the underlying stock, the fixed-income part, and the interaction
Xiaoyu Tan   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Kepemimpinan Hamba Tuhan Menurut Matius 20:25-28

open access: yesEvangelikal: Jurnal Teologi Injili dan Pembinaan Warga Jemaat, 2019
: The leadership of God's servant raises a polemic because there are still those who think about God's servant being only servant and not being leader, however, in that opinion it is true.
Hannas Hannas, Rinawaty Rinawaty
doaj   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Storage solutions for roots and tubers in Ethiopia through traditional and improved methods

open access: yesDiscover Food
Roots and tubers are essential crops worldwide, face storage challenges in Ethiopia due to perishability and moisture content. This review explores literature on storage methods, their significance, challenges, and opportunities related to Potatoes ...
Nezif Abamecha   +2 more
doaj   +1 more source

Drying and smoking of fish: nutritional significance, safety concerns and emerging technologies for food security

open access: yesJournal of Fisheries
The global demand for fish and fishery products has heightened the need for effective preservation methods to ensure food security and reduce post-harvest losses.
Nidhi Singh Sengar   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

From soil to health: advancing regenerative agriculture for improved food quality and nutrition security

open access: yesFrontiers in Nutrition
Industrial agriculture practices including herbicide-pesticide usage, synthetic fertilizer application, large-scale monocropping, and tillage contribute to increasing concentrations of atmospheric carbon dioxide (CO2), exacerbating the effects of global ...
Carl L. Rosier   +6 more
doaj   +1 more source

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