Results 61 to 70 of about 1,016,481 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Storage solutions for roots and tubers in Ethiopia through traditional and improved methods

Discover Food
Roots and tubers are essential crops worldwide, face storage challenges in Ethiopia due to perishability and moisture content. This review explores literature on storage methods, their significance, challenges, and opportunities related to Potatoes ...
Nezif Abamecha, Tolcha Techane, Muhammed Adem   +2 more
doaj   +1 more source

Drying and smoking of fish: nutritional significance, safety concerns and emerging technologies for food security

Journal of Fisheries
The global demand for fish and fishery products has heightened the need for effective preservation methods to ensure food security and reduce post-harvest losses.
Nidhi Singh Sengar, Vriddhi Sahu, Jitender Kumar Jakhar, Domendra Dhruve, Soibam Ngasotter, . Tameshwar, M.K. Gendley, Sunita Jakhar   +7 more
doaj   +1 more source

Antibiotic resistance genes in manure-amended soil and vegetables at harvest.

Journal of Hazardous Materials, 2015
Lettuce and endive, which can be eaten raw, were planted on the manure-amended soil in order to explore the influence of plants on the abundance of antibiotic resistance genes (ARGs) in bulk soil and rhizosphere soil, and the occurrence of ARGs on ...
Feng-Hua Wang, M. Qiao, Zheng Chen, Jianqiang Su, Yong-guan Zhu   +4 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

From soil to health: advancing regenerative agriculture for improved food quality and nutrition security

Frontiers in Nutrition
Industrial agriculture practices including herbicide-pesticide usage, synthetic fertilizer application, large-scale monocropping, and tillage contribute to increasing concentrations of atmospheric carbon dioxide (CO2), exacerbating the effects of global ...
Carl L. Rosier, Anya Knecht, Anya Knecht, Jasia S. Steinmetz, Amy Weckle, Kelly Bloedorn, Erin Meyer   +6 more
doaj   +1 more source

A HapMap harvest of insights into the genetics of common disease.

Journal of Clinical Investigation, 2008
The International HapMap Project was designed to create a genome-wide database of patterns of human genetic variation, with the expectation that these patterns would be useful for genetic association studies of common diseases.
T. Manolio, L. Brooks, F. Collins
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Navigating the Fault Lines in Civic Food Networks

Journal of Agriculture, Food Systems, and Community Development, 2016
Civic food networks have emerged as a civil society–driven response to the social, economic, and environmental shortcomings of the industrial food system.
Colin Ray Anderson, Wayne McDonald, Jo-Lene Gardiner, Stéphane M. McLachlan   +3 more
doaj   +1 more source