Results 71 to 80 of about 550,312 (276)
FoodsMango seed kernels, an underutilized by-product of the mango pulping industries, are a rich supplier of metabolites, specifically phenolic and flavonoid compounds. These compounds have potential health benefits.
Poonam Choudhary +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The incidence of post-harvest problems among small farmers surveyed in three regions of the Limpopo Province [PDF]
High yielding varieties and new production technology have vastly increased the world's agricultural production and provided rural incomes and affordable food for large parts of the population.
Randela, Rendani
core
Entropy, 2013 The paper introduces the notion of “entropy harvesting” in physical and biological systems. Various physical and natural systems demonstrate the ability to decrease entropy under external stimuli. These systems, including stretched synthetic polymers, muscles, osmotic membranes and suspensions containing small hydrophobic particles, are called ...
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
International Journal of Bio-Resource and Stress ManagementThe experiment was conducted from January to August, 2023 at Central Institute of Fisheries Education, Mumbai, Maharashtra, India, to evaluate nutritionally rich restructured fish products, such as sausages, using mantis shrimp (Miyakella nepa).
D. Varsha +6 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
International Journal of MicrobiologyAntibiotics are molecules produced by a microbe to inhibit the growth of another microbe. Due to prolonged improper use, the situation in which these antibiotics do not work effectively on these microbes is termed antibiotic resistance or antimicrobial ...
Shama Afroze +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source