Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Assessment of Agronomic and Physiological Traits in Bread Wheat Genotypes Under Soil Salinity Stress
ISPEC Journal of Agricultural SciencesHigh soil salinity is a common abiotic stress factor that seriously affects crop production, particularly in semi-arid regions of the world. In order to investigate the effect of soil salinity stress on agronomic and physiological traits of bread wheat ...
Somayyeh RAZZAGHI
doaj +1 more source
Diversity increases yield but reduces harvest index in crop mixtures. [PDF]
Nat Plants, 2021 Chen J +5 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Effect of available soil water on leaf development and dry matter partitioning in 4 cultivars of peanut (Arachis hypogaea L.) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2004 Water stress brings about changes in growth and dry matter partition in peanut plants and the changes vary depending on peanut cultivars. The objectives of this study were to investigate the effect of 3 regimes of available soil water on leaf development
Aran Patanothai +4 more
doaj
Effect of Flowering Time-Related Genes on Biomass, Harvest Index, and Grain Yield in CIMMYT Elite Spring Bread Wheat. [PDF]
Biology (Basel), 2021 Dreisigacker S +7 more
europepmc +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Two Novel QTLs for the Harvest Index that Contribute to High-Yield Production in Rice (Oryza sativa L.). [PDF]
Rice (N Y), 2021 Saito H +7 more
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source