Results 91 to 100 of about 365,168 (303)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Exploring the limits of crop productivity: A model to evaluate progress [PDF]
The goal was to determine the limits of crop productivity when all environmental constraints were removed. Researchers define productivity as food output per unit of input.
Bugbee, Bruce
core +1 more source
A catch-free stock assessment model with application to goliath grouper (Epinephelus itajara) off southern Florida [PDF]
, 2006 Many modern stock assessment methods provide the machinery for determining the status of a stock in relation to certain reference points and for estimating how quickly a stock can be rebuilt. However, these methods typically require catch data, which are
Eklund, Anne-Marie +2 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Physio-morphological appraisal of aromatic fine rice (Oryza sativa L.) in relation to yield potential [PDF]
, 2011 A field experiment was conducted to determine the physio-morphological attributes in relation to yield potential of modern and aromatic rice varieties. The experiment was laid out in a randomized complete block design (RCBD) with five replications.
Mia, Md. Abdul Baset +1 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Agronomic changes of soybean cultivars released during 1950 to 2006 in Heilongjiang Province
浙江大学学报. 农业与生命科学版, 2008 To clarify the aim characteristics for soybean high-yield breeding, soybean cultivars released during 1950 to 2006 in Heilongjiang Province were used to investigate agronomic characteristics.
JIN Jian +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Effect of nitrogen on safflower physiology and productivity [PDF]
, 2012 Safflower (Carthamus tinctorius L.) is an oil-crop suitable for semi-arid agriculture, but its physiological response to agronomic inputs has yet to be fully evaluated.
Fuller, MP, Jellings, AJ, Mohamed, SJ
core +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source