Results 71 to 80 of about 73,078 (260)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Pesquisa Agropecuária Brasileira, 2007 The objective of this study was to assess the impact of genetic breeding on grain yield, and to identify the physiological traits associated to the increment in yield and their related growth processes, for wheat cultivars grown in Southern Brazil, in ...
Osmar Rodrigues +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Environment Conservation JournalThe aim of the current study was to evaluate 20 genotypes of greengram throughout the Kharif season of 2024 to determine genetic variability, correlation, and path analysis for yield and yield-contributing traits.
Juhee Kumari, Ann Maxton
doaj +1 more source
Can Reduced Irrigation Mitigate Ozone Impacts on an Ozone-Sensitive African Wheat Variety?
Plants, 2019 Ground-level ozone (O3) pollution is known to adversely affect the production of O3-sensitive crops such as wheat. The magnitude of impact is dependent on the accumulated stomatal flux of O3 into the leaves.
Harry Harmens +4 more
doaj +1 more source
Red fescue and redtop harvest index
, 2004 Harvest index is an important indicator of seed production efficiency. Its importance is related to dramatic increases of crop yields that occurred in the twentieth century. Harvest index reflects distribution of photosynthates between the grain and the vegetative part of the plant, as well as carbon allocation in grain crop.
Simić, Aleksandar +3 more
openaire +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source