Results 71 to 80 of about 365,168 (303)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

B-HIT - A Tool for Harvesting and Indexing Biodiversity Data

PLOS ONE, 2015
With the rapidly growing number of data publishers, the process of harvesting and indexing information to offer advanced search and discovery becomes a critical bottleneck in globally distributed primary biodiversity data infrastructures. The Global Biodiversity Information Facility (GBIF) implemented a Harvesting and Indexing Toolkit (HIT), which ...
Patricia Kelbert, Gabriele Droege, Katharine Barker, Kyle Braak, E. Margaret Cawsey, Jonathan Coddington, Tim Robertson, Jamie Whitacre, Anton   +8 more
openaire   +6 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Genetic variability for different biometric traits in wheat (Triticum aestivum L.) under medium fertility conditions [PDF]

Electronic Journal of Plant Breeding, 2014
This study was carried out at CCS HAU, Regional Research Station, Bawal (Haryana) during rabi 2012-13 with 24 wheat genotypes to assess the genetic variability, correlation and path coefficient analysis under medium fertility conditions.
Y. Kumar*, R.A.S. Lamba And R.P. Saharan1
doaj  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Agronomic characteristics of the spring forms of the wheat landraces (einkorn, emmer, spelt, intermediate bread wheat) grown in organic farming [PDF]

, 2010
Organic farmers look to the possibilities of growing neglected crops, such as the spring forms of hulled wheat – einkorn, emmer and spelt – for support in developing the organic farming system.
D Cudney, D McVey, E Gregová, E Marconi, E-SM Abdel-Aal, G Belay, G Kema, J Eisele, J Frégeau-Reid, J Moudrý, J Schmid, J Sehnalová, K Hammer, K Hammer, K Müller, M Gooding, M Marconi, M Wolfe, P Konvalina, S Herrera-Foessel, U Köpke   +20 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Zeolite Use Efficiency Variation under Water Deficit Stress in Grass Pea and Lentil [PDF]

Журнал Сибирского федерального университета: Серия Биология, 2016
To evaluate the effect of different application rates of zeolites under drought stress conditions on the protein and biomass production, and zeolite use efficiency in grass pea (Lathyrus sativus L.) and lentil (Lens culinaris L.), two-way ANOVA based on ...
Alireza Pirzad, Sevil Mohammadzadeh
doaj  

Pertimbangan Visual dan Fisiologis sebagai Kriteria Panen Kangkung Darat Akibat Pemberian Kapur Dolomit di Tanah Gambut [PDF]

, 2015
The giving of dolomite lime as the treatment was done as many as 3 dose level, namely: D1 = 3 tons ha-1; D2 = 6 tons ha-1 and D3 = 9 tons ha-1 as many as 9 replications.
Susilo, D. E. (Djoko)
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source