Results 61 to 70 of about 447,172 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Social issues of power harvesting as key enables of WSN in pervasive computing [PDF]

, 2012
Pervasive systems have gained popularity and open the door to new applications that will improve the quality of life of the users. Additionally, the implementation of such systems over an infrastructure of Wireless Sensor Networks has been proven to be ...
J. Mabe, Grabham, N. J., J. Berzosa, M. J. Tudor, Mabe, J., Tudor, M. J., Berzosa, J., N. J. Grabham   +7 more
core   +1 more source

Damage Caused by Wheeled Skidders on Cambisols of Central Europe

Croatian Journal of Forest Engineering, 2015
Machine traffic and timber skidding significantly affect the soil surface and soil properties. The effects are mostly negative and result in soil erosion, worsening of soil properties and inhibition of the growth of roots and soil organisms.
Michal Ferenčík, Martin Jankovský, Miroslav Stanovský, Valéria Messingerová, Michal Allman   +4 more
doaj  

Design, Fabrication and Temperature Sensitivity Testing of a Miniature Piezoelectric-Based Sensor for Current Measurements

Actuators, 2014
Grid capacity, reliability, and efficient distribution of power have been major challenges for traditional power grids in the past few years. Reliable and efficient distribution within these power grids will continue to depend on the development of ...
Steven B. Lao, Shamsheer S. Chauhan, Tim E. Pollock, Thorben Schröder, In Sik Cho, Armaghan Salehian   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

OAI-PMH for Resource Harvesting

, 2005
A variety of examples have arisen in which the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH) has been used for applications beyond bibliographic metadata interchange.
Van de Sompel, Herbert, Nelson, Michael L.   +1 more
core  

Exposing and harvesting metadata using the OAI Metadata Harvesting Protocol : a tutorial [PDF]

, 2001
In this article I outline the ideas behind the Open Archives Initiative metadata harvesting protocol (OAIMH), and attempt to clarify some common misconceptions. I then consider how the OAIMH protocol can be used to expose and harvest metadata.
Warner, Simeon, Warner, Simeon M.
core  

Harvesting energy from magnetic fields to power condition monitoring sensors

, 2013
Condition monitoring is playing an increasingly important role within electrical power networks, where its use can help to reduce maintenance costs, improve supply reliability and permit increased utilization of equipment capacity by providing a measure ...
Judd, Martin, Roscoe, Nina
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The chlorosome: a prototype for efficient light harvesting in photosynthesis [PDF]

, 2010
Three phyla of bacteria include phototrophs that contain unique antenna systems, chlorosomes, as the principal light-harvesting apparatus. Chlorosomes are the largest known supramolecular antenna systems and contain hundreds of thousands of BChl c/d/e ...
van Amerongen, H., Amerongen, H., van, Gert T. Oostergetel, Boekema, E.J., van Amerongen, Herbert, Boekema, Egbert J.,, Oostergetel, Gert T.,, Amerongen, Herbert van,, Oostergetel, G., Oostergetel, Gert T., Egbert J. Boekema, Boekema, Egbert J., Herbert van Amerongen   +12 more
core   +1 more source