Results 61 to 70 of about 524,624 (282)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Optimization of voltage doublers for energy harvesting applications [PDF]

, 2013
Energy harvesting is increasingly enabling the expansion of wireless sensor networks in challenging applications by replacing batteries in low power sensors. Many forms of energy harvester suffer from low output voltage which can be partially compensated
Judd, Martin, Roscoe, Nina
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Optimal Partial Harvesting Schedule for Aquaculture Operations [PDF]

When growth is density dependent, partial harvest of the standing stock of cultured species (fish or shrimp) over the course of the growing season (i.e., partial harvesting) would decrease competition and thereby increase individual growth rates and ...
Leung, PingSun, Yu, Run
core  

Design, Fabrication and Temperature Sensitivity Testing of a Miniature Piezoelectric-Based Sensor for Current Measurements

Actuators, 2014
Grid capacity, reliability, and efficient distribution of power have been major challenges for traditional power grids in the past few years. Reliable and efficient distribution within these power grids will continue to depend on the development of ...
Steven B. Lao, Shamsheer S. Chauhan, Tim E. Pollock, Thorben Schröder, In Sik Cho, Armaghan Salehian   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessing the influence of ground-based LiDAR devices, processing solutions, and forest stand characteristics on tree diameter and height estimation

Central European Forestry Journal
Diameter at breast height (DBH) and tree height (TH) are essential parameters for accurately estimating tree volume, biomass, and other forest metrics. Conventional measurement methods often involve considerable time investment, which has motivated the ...
Výbošťok Jozef, Chudá Juliána, Skladan Michal, Tomčík Daniel, Singh Arunima, Mokroš Martin   +5 more
doaj   +1 more source

Choosing the right close-range technology for measuring DBH in fast-growing trees plantations

Trees, Forests and People
Recently, the cultivation of fast-growing tree (FGT) plantations has gained importance due to the growing energy and climate crisis. FGT plantations have the potential to reduce carbon footprints and lower greenhouse gas emissions by utilization of local
Michal Skladan, Juliána Chudá, Arunima Singh, Matej Masný, Martin Lieskovský, Michal Pástor, Martin Mokroš, Jozef Vyboštok   +7 more
doaj   +1 more source