Results 81 to 90 of about 524,624 (282)
Frontiers in Remote SensingShort-rotation plantations of fast-growing trees (FGT) offer a sustainable biomass source to mitigate climate change and boost rural energy self-sufficiency. Accurate estimation of woody above-ground biomass (AGB) is critical for efficient management and
Michal Skladan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
BioResourcesThe monitoring of forest biomass stock volumes in larger operations is typically conducted irregularly, either by tracking cargo arrivals or by using simple manual measurement methods.
Miloš Gejdoš +2 more
doaj
Predicting the annual erosion rates on a small stream by the BANCS model
Soil and Water Research, 2019 The erosion of streambanks causes soil loss and degrades the stream habitat. To optimize the prevention of bank erosion, we first need to determine the most vulnerable places on banks. This can be done by the BANCS model.
Zuzana Allmanová +4 more
doaj +1 more source
A Prototype Harvester For Chickpea Harvesting
Research in Agricultural SciencesTo meet the needs of Iranian farmers who grow rainfed chickpeas, a new harvester was developed and tested. The project began with a modified stripper harvester and continued with a new design. The main components of the machine, such as the platform, reel, chassis and power transmission system, were improved to enhance its work quality.
Hiwa Golpıra, Kaywan Mahmoodı
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Energies, 2018 Thermoelectric generators (TEGs) are rapidly becoming the mainstream technology for converting thermal energy into electrical energy. The rise in the continuous deployment of TEGs is related to advancements in materials, figure of merit, and methods for ...
Ravi Anant Kishore +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source