Results 91 to 100 of about 447,172 (311)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A low-cost MLS prototype for voxel-based above-ground biomass estimation in short-rotation plantations

Frontiers in Remote Sensing
Short-rotation plantations of fast-growing trees (FGT) offer a sustainable biomass source to mitigate climate change and boost rural energy self-sufficiency. Accurate estimation of woody above-ground biomass (AGB) is critical for efficient management and
Michal Skladan, Arunima Singh, Juliana Chudá, Martin Lieskovský, Matej Masný, Jozef Vyboštok   +5 more
doaj   +1 more source

A Prototype Harvester For Chickpea Harvesting

Research in Agricultural Sciences
To meet the needs of Iranian farmers who grow rainfed chickpeas, a new harvester was developed and tested. The project began with a modified stripper harvester and continued with a new design. The main components of the machine, such as the platform, reel, chassis and power transmission system, were improved to enhance its work quality.
Hiwa Golpıra, Kaywan Mahmoodı
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Vibration energy harvesting using the Halbach array

, 2012
This paper studies the feasibility of vibration energy harvesting using a Halbach array. A Halbach array is a specific arrangement of permanent magnets that concentrates the magnetic field on one side of the array while cancelling the field to almost ...
Beeby, Steve, Zhu, Dibin, Harris, Nick, Tudor, John   +3 more
core   +1 more source

On the design of an energy-harvesting noise-sensing WSN mote [PDF]

, 2014
Wireless sensor networks (WSNs) could potentially help in the measurement and monitoring of noise levels, an important step in mitigating and fighting noise pollution.
Tan, Wilson M., Jarvis, Stephen A.; id_orcid, Wilson M Tan, Stephen A Jarvis, Jarvis, Stephen A.   +4 more
core   +1 more source

Analysis and Comparison of Methods for Determining Small Piles of Wood Chips Using Laser Scanning Technology

BioResources
The monitoring of forest biomass stock volumes in larger operations is typically conducted irregularly, either by tracking cargo arrivals or by using simple manual measurement methods.
Miloš Gejdoš, Martin Lieskovský, Michal Ferenčík   +2 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Rainwater Harvesting Potential for Domestic Water Supply in Edo State [PDF]

In the face of increasing scarcity of water resources, there is a need for communities to undertake audits of their current rainwater harvesting potential as a practical and promising alternative solution for water shortage.
S. I. Oni, Emmanuel Ege
core