Results 91 to 100 of about 298,774 (265)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mixed-effects neural network modelling to predict longitudinal trends in fasting plasma glucose

BMC Medical Research Methodology
Background Accurate fasting plasma glucose (FPG) trend prediction is important for management and treatment of patients with type 2 diabetes mellitus (T2DM), a globally prevalent chronic disease.
Qiong Zou, Borui Chen, Yang Zhang, Xi Wu, Yi Wan, Changsheng Chen   +5 more
doaj   +1 more source

Development and preliminary evaluation of the Chinese adult dietary behavior scale

Frontiers in Nutrition
BackgroundThere is currently no widely accepted multidimensional tool to assess adult dietary behaviors in China. This study developed the Chinese Adults Dietary Behavior Scale (CADBS) to evaluate Chinese adults’ eating-related traits and preliminarily ...
Haiyue Zhang, Xinrui Li, Xinrui Li, Yuan Wang, Wei Zhang, Ying Liang, Yue Wang, Zhe Yang, Zhijun Tan, Junrong Xu, Lei Shang   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A multistate transition model for survival estimation in randomized trials with treatment switching and a cured subgroup

BMC Medical Research Methodology
Although many methods have been proposed on the overall survival estimation in randomized trials permitting treatment switching after the progressive disease (PD), the cured subgroup of patients within these trials has not been fully considered.
Haixia Hu, Ling Wang, Kejian Wu, Wei Ge, Jielai Xia, Chen Li   +5 more
doaj   +1 more source

HBsAg and anti-HBs coexistence in patients with HBV in acute and chronic phases

Virus Research
HBsAg and anti-HBs coexistence represents an unusual serological pattern in hepatitis B virus (HBV) infection. However, its natural course remains unclear.
Zhongshu Pu, Zhaohua Ji, Haixia Su, Ting Fu, Zhongjun Shao, Yongping Yan   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Preschool children’s eating behaviors and caregivers’ feeding practices in relation to children’s weight in China: a network analysis

Annals of Medicine
Objective This study aimed to characterize the interactions between preschool children’s eating behaviors and their caregivers’ feeding practices, and to compare these patterns across underweight, normal weight, and overweight/obesity groups using a ...
Haiyue Zhang, Zhe Yang, Hao Zhang, Jing Yuan, Xianjun Yang, Ying Liang, Zhijun Tan, Yue Wang, Wei Zhang, Yuhai Zhang, Xun Jiang, Lei Shang   +11 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Altered regional brain activity and functional connectivity in relation to blood lead levels

Environmental Sciences Europe
Background Lead is a prevalent heavy metal pollutant in the environment, and chronic lead exposure in occupational settings has been linked to cognitive decline. Our objective was to delineate lead-induced changes in brain functional activity through the
Yi Shi, Linfeng Yan, Yang Yang, Fenfen He, Wenhao Li, Jianbin Zhang, Fang Zhao, Diya Wang, Wen Wang, Zaihua Zhao, Xuefeng Shen   +10 more
doaj   +1 more source