Results 101 to 110 of about 5,246,438 (234)

Cold exposure accelerates lysine catabolism to promote cold acclimation via remodeling hepatic histone crotonylation

Environment International
Background: Cold environments pose serious threats on human health, with increased risk for myocardial infarction, stroke, frostbite, and hypothermia. Acquired cold acclimation is required to minimize cold-induced injures and to improve metabolic health.
Chong Xue, Sijin Zhu, Yang Li, Xiaoming Chen, Liang Lu, Peng Su, Qian Zhang, Xinqin Liu, Ruili Guan, Zongcai Liu, Zhiwei Zhao, Shan Tang, Jingyuan Chen, Jianbin Zhang, Wenbin Zhang, Huanyu Lu, Wenjing Luo   +16 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Arctic Ocean Acidification Assessment: Summary for Policymakers [PDF]

, 2013
Executive summary of the 2013 Arctic Ocean Acidification Assessment, including an update on the state of ocean acidification in the Arctic and how that acidification is impacting on the Arctic marine environment. It outlines each of the ten key findings
Arctic Monitoring and Assessment Programme
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ameliorating effects of rTMS on spermatogenesis disorder caused by cranial radiation-induced abscopal effects

Ecotoxicology and Environmental Safety
The study investigated the potential ameliorating effects of repetitive transcranial magnetic stimulation (rTMS) on spermatogenesis disorder caused by cranial radiation-induced abscopal effects (RIAEs).
Ling Guo, Liyuan Liu, Yan Zhou, Tongzhou Qin, Fuli Wang, Jianzhe Li, Jiangyi Li, Guiqiang Zhou, Peng Gao, Jingwen Wang, Wei Li, Jing Li, Guirong Ding   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation sequencing: Study of a severe case of Rickettsia japonica infection

Infectious Medicine
Background: In this study, we present a case of Japanese spotted fever (JSF) caused by Rickettsia japonica and use this case to investigate the process of diagnosing and reintegrating traceability of infectious diseases via metagenomic next-generation ...
Zhenhua Lu, Jing Han, Yuanyuan Wang, Zhen He, Shuxuan Song, Kun Liu, Zhongjun Shao   +6 more
doaj   +1 more source