Results 31 to 40 of about 311,763 (246)

Alterations in static and dynamic topological properties of brain functional network after chronic high altitude exposure: a panel study

Frontiers in Aging Neuroscience
BackgroundLong-term exposure to a high-altitude (HA) hypoxic environment induces cognitive impairments, but the underlying mechanisms remain unclear. Notably, the specific topological features of brain networks in this context have not been thoroughly ...
Siyao Zeng, Yang Zhou, Sijia Guo, Yang Ou, Tingting Yang, Chong Xue, Xinqin Liu, Jie Liu, Jianbin Zhang, Wenjing Luo, Xiaoming Chen   +10 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Chronic high-altitude exposure and cognitive health in Chinese college students: a 4-year longitudinal neuroimaging study

Scientific Reports
High-altitude environments pose significant challenges to human cognition due to hypoxic conditions. The long-term effects of chronic high-altitude exposure on cognitive functions remain poorly understood.
Hong Li, Qian Zhang, Siyao Zeng, Yang Zhou, Xinqin Liu, Wenbin Zhang, Wenjing Luo, Yazhuo Kong, Xiaoming Chen   +8 more
doaj   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Association between pre-S/S amino acid variations of hepatitis B virus and hepatitis B surface antigen clearance

Zhongguo gonggong weisheng
ObjectiveAnalysis of the association between hepatitis B surface antigen (HBsAg) clearance and amino acid mutations in the pre-S/S region of the hepatitis B virus (HBV) in a cohort from Wuwei city, Gansu province.
Yuemei WANG, Xiaojie YUAN, Weilu ZHANG, Zhaohua JI, Zhen HE, Ting FU, Weikang WU, Haowei ZHOU, Yijun LI, Linli XU, Wenhua ZHANG, Wenling JIA, Chunhui LIANG, Haitao TANG, Fengmei WANG, Chunmei ZHAO, Zhongjun SHAO   +16 more
doaj   +1 more source

Simulations of neighboring-layout-induced electromagnetic dose variations in experimental animals

Fushe yanjiu yu fushe gongyi xuebao, 2023
In this study, the issues of unclear characteristics of dose differences in multi-frequency and large-sample bioelectromagnetic exposure systems were studied. For this, four contrast simulation environments were established using Sim4Life.
GUO Juan, DU Dan, LI Jing, LIN Jiajin
doaj   +1 more source

Sustained Therapeutic Efficacy of Intravenous Plasminogen Concentrate in Pediatric Patients With Type 1 Plasminogen Deficiency: An Analysis of Dosing Parameters and Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Type 1 plasminogen deficiency (PLGD‐1) is an ultra‐rare autosomal recessive disorder caused by variants in the PLG gene and affects approximately 1.6 individuals per million. The condition is characterized by decreased plasminogen levels and impaired function, resulting in fibrin‐rich lesions on mucous membranes throughout the body.
Charles Nakar, Karen Thibaudeau, Mary Mathias, Heather McDaniel, Madlen Reschke, Klaus Tenbrock, Joseph M. Parker, Amy Shapiro   +7 more
wiley   +1 more source

Nicotinamide Riboside Alleviates the Neurotoxic Injury of Dendritic Spine Plasticity Mediated by Hypoxic Microglial Activation

Biomolecules
Exposure to hypoxia at high altitudes is significantly associated with impairments in learning and memory functions, as well as abnormalities in neuronal function and synaptic plasticity.
Jinchao Hou, Haowei Zhang, Xiaodong Huo, Ruili Guan, Boxuan Wang, Yuchen Wang, Fang Zhao, Xinqin Liu, Yang Hu, Congcong Zhuang, Yuankang Zou   +10 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Effects of access to primary healthcare services on health vulnerability among older adults in China: focusing on demographic differences

Frontiers in Public Health
BackgroundAgainst the backdrop of an aging population, older adults are confronted with multifaceted challenges, including physiological decline, uneven distribution of medical resources, and economic constraints, which collectively exacerbate their ...
Ningli Zhu, Ningli Zhu, Ningli Zhu, Jun Li, Xiaohui Liu, Lei Luo, Lei Luo, Lei Luo, Wenwen Cheng, Wenwen Cheng, Wenwen Cheng, Xiaoyu Li, Xiaoyu Li, Xiaoyu Li, Chen Yu, Chen Yu, Chen Yu, Siyu Zhang, Siyu Zhang, Siyu Zhang, Liang Zhu, Liang Zhu, Liang Zhu   +22 more
doaj   +1 more source