Results 111 to 120 of about 3,726,940 (286)

An Approach to Assessing the Influence of Environmental and Occupational Cancer Hazard Identification on Policy Decision-Making. [PDF]

Environ Health Perspect, 2023
Mehta SS, Morin I, Osborn K, Lemeris CR, Conti M, Lunn RM.   +5 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association between childhood maltreatment patterns and comorbidity of depression and anxiety in left-behind children: a latent class analysis

BMC Psychiatry
Background Childhood maltreatment (CM) represents a significant risk factor for depression and anxiety symptoms, with left-behind children (LBC) demonstrating heightened exposure.
Yudu Liu, Bing Xiang, Jiangxue Wang, Xian Wu, Yanming Li, Can Jiang, Mei Yang, Xinyan Xie, Feng Zhou, Jing Zeng   +9 more
doaj   +1 more source

Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases

Frontiers in Immunology
Outbreaks of emerging and re-emerging infectious diseases have consistently threatened human health. Since vaccinations are a powerful tool for preventing infectious illnesses, developing new vaccines is essential.
Zhihan Zhang, Yumeng Yang, Liwen Huang, Lei Yuan, Sijian Huang, Zihang Zeng, Yuan Cao, Yuan Cao, Xianghong Wei, Xiaomei Wang, Mingsong Shi, Maohua Zhong   +11 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engaging students in OH&S hazard identification through a game

, 2013
Engaging students in OH&S hazard identification through a ...
Susanne Tepe (13396308), Stefan Greuter (13096110)   +1 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Associations between perceived overload and quality of care in dementia family caregivers in China: mediating role of familism and social support

Frontiers in Public Health
BackgroundThe quality of care (QoC) of people with dementia is an issue of widespread concern in public health. While perceived overload of family caregivers is thought to negatively affect QoC, the underlying mechanisms of this relationship are not well
Ni Zou, Chan Cai, Xinyu Zhou, Shunian Chen, Jiabi Shi, Chongqing Shi   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The effectiveness of the intervention model based on cognitive behavioral therapy in reducing risky sexual behaviors among MSM

Frontiers in Public Health
MethodsBased on CBT theory and the Internet, we established an intervention model targeting high-risk sexual behavior patterns in MSM. We then conducted a randomized controlled trial (n = 50) to assess the impact of the CBT-based intervention on high ...
Xiaochen Xiang, Xiaobing Zhai, Yumeng Lei, Jialu Feng, Qiang Wang   +4 more
doaj   +1 more source