Results 151 to 160 of about 6,418,358 (332)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The restricted mean survival time as a replacement for the hazard ratio and the number needed to treat in long-term studies. [PDF]
ESC Heart Fail, 2021 Messori A, Bartoli L, Trippoli S.
europepmc +1 more source
Experience of Crisis-Hit Asian Countries: Do Asset Management Companies Increase Moral Hazard? [PDF]
This paper examines the performances of Asian asset management companies (AMCs). The analysis reveals that the AMCs vary significantly in their design and performances.
Pasadilla, Gloria +1 more
core
Protein O‐glycosylation in the Bacteroidota phylum
FEBS Open Bio, EarlyView.Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns +2 more
wiley +1 more source
Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate. [PDF]
BMC Med Res Methodol, 2021 MacKenzie TA +2 more
europepmc +1 more source
Comorbid conditions explain the association between posttraumatic stress disorder and incident cardiovascular disease [PDF]
, 2019 Background Posttraumatic stress disorder ( PTSD ) is associated with risk of cardiovascular disease ( CVD ). Biopsychosocial factors associated with PTSD likely account for some or all of this association.
Chard, Kathleen M +10 more
core +1 more source
FEBS Open Bio, EarlyView.We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado +4 more
wiley +1 more source
Analysis of odds, probability, and hazard ratios: From 2 by 2 tables to two-sample survival data [PDF]
, 2019 Zhiqiang Tan
openalex +1 more source