How Do the Accrual Pattern and Follow-Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated? [PDF]
Oncologist, 2019 In randomized clinical trials, the magnitude of the treatment effect is often reported using the hazard ratio (HR) even when the proportional hazards (PH) assumption is not met.
Horiguchi M, Hassett MJ, Uno H.
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Estimation of the ratio of hazard functions [PDF]
, 1982 In a clinical trial in which comparison of survival across treatment groups is of interest, it is useful to have a descriptive measure of the difference in survival between groups. If the hazard functions in two groups are roughly proportional, then the ratio of hazard functions has the interpretation of relative risk and has intuitive appeal as a ...
Crowley, John +2 more
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On the Interpretation of the Hazard Ratio and Communication of Survival Benefit. [PDF]
Oncologist, 2017 This brief communication will clarify the difference between a relative hazard and a relative risk. We highlight the importance of this difference, and demonstrate in practical terms that 1 minus the hazard ratio should not be interpreted as a risk ...
Sashegyi A, Ferry D.
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The median hazard ratio: a useful measure of variance and general contextual effects in multilevel survival analysis. [PDF]
Stat Med, 2017 Multilevel data occurs frequently in many research areas like health services research and epidemiology. A suitable way to analyze such data is through the use of multilevel regression models (MLRM). MLRM incorporate cluster‐specific random effects which
Austin PC, Wagner P, Merlo J.
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Hazard Ratio in Clinical Trials [PDF]
Antimicrobial Agents and Chemotherapy, 2004 Time-to-event curves analyzed by Cox proportional hazards regression are commonly used to describe the outcome of drug studies. This methodology has the advantage of using all available information, including patients who fail to complete the trial, such as in cancer chemotherapy or human immunodeficiency virus antiviral treatment studies.
Spotswood L. Spruance +3 more
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Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. [PDF]
J Clin Oncol, 2014 In a longitudinal clinical study to compare two groups, the primary end point is often the time to a specific event (eg, disease progression, death). The hazard ratio estimate is routinely used to empirically quantify the between-group difference under ...
Uno H +15 more
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Hazard Ratio Analysis of Laparoscopic Radical Hysterectomy for IA1 With LVSI-IIA2 Cervical Cancer: Identifying the Possible Contraindications of Laparoscopic Surgery for Cervical Cancer [PDF]
Frontiers in Oncology, 2020 Objectives: This study aimed to compare the 5-year disease-free survival (DFS) and overall survival (OS) of laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH) for IA1 with lymphovascular space invasion (LVSI)-IIA2 cervical ...
Pengfei Li +8 more
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smoothHR: an R package for pointwise nonparametric estimation of hazard ratio curves of continuous predictors. [PDF]
Comput Math Methods Med, 2013 The Cox proportional hazards regression model has become the traditional choice for modeling survival data in medical studies. To introduce flexibility into the Cox model, several smoothing methods may be applied, and approaches based on splines are the ...
Meira-Machado L +3 more
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Optimal approximate conversions of odds ratios and hazard ratios to risk ratios
Biometrics, 2020 AbstractOdds ratios approximate risk ratios when the outcome under consideration is rare but can diverge substantially from risk ratios when the outcome is common. In this paper, we derive optimal analytic conversions of odds ratios and hazard ratios to risk ratios that are minimax for the bias ratio when outcome probabilities are specified to fall in ...
T. VanderWeele
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Bayesian test for hazard ratio in survival analysis. [PDF]
Springerplus, 2016 Over the decades, testing for equivalence of hazard functions has received a wide attention in survival analysis. In this paper, we proposed a Bayesian test to address this testing equivalence problem, Most of all, proposed test is methodologically flexible so that a procedure determining weights is not required when the proportional assumption is ...
Kim G, Lee SW.
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