Hazard Ratio in Clinical Trials [PDF]
Antimicrobial Agents and Chemotherapy, 2004 Time-to-event curves analyzed by Cox proportional hazards regression are commonly used to describe the outcome of drug studies. This methodology has the advantage of using all available information, including patients who fail to complete the trial, such as in cancer chemotherapy or human immunodeficiency virus antiviral treatment studies.
Spotswood L, Spruance +3 more
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Instrumental Variable Estimation of the Causal Hazard Ratio
Biometrics, 2022 AbstractCox's proportional hazards model is one of the most popular statistical models to evaluate associations of exposure with a censored failure time outcome. When confounding factors are not fully observed, the exposure hazard ratio estimated using a Cox model is subject to unmeasured confounding bias.
Linbo Wang +3 more
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Odds ratio, hazard ratio and relative risk
Advances in Methodology and Statistics, 2016 Odds ratio (OR) is a statistic commonly encountered in professional or scientific medical literature. Most readers perceive it as relative risk (RR), although most of them do not know why that would be true. But since such perception is mostly correct, there is nothing (or almost nothing) wrong with that.
Janez Stare, Delphine Maucort-Boulch
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Optimal approximate conversions of odds ratios and hazard ratios to risk ratios
Biometrics, 2020 AbstractOdds ratios approximate risk ratios when the outcome under consideration is rare but can diverge substantially from risk ratios when the outcome is common. In this paper, we derive optimal analytic conversions of odds ratios and hazard ratios to risk ratios that are minimax for the bias ratio when outcome probabilities are specified to fall in ...
T. VanderWeele
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Causal interpretation of the hazard ratio in randomized clinical trials. [PDF]
Clin TrialsBackground: Although the hazard ratio has no straightforward causal interpretation, clinical trialists commonly use it as a measure of treatment effect. Methods: We review the definition and examples of causal estimands.
Fay MP, Li F.
europepmc +2 more sources
Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions. [PDF]
Eur Heart J, 2019 Aims Ambient air pollution is a major health risk, leading to respiratory and cardiovascular mortality. A recent Global Exposure Mortality Model, based on an unmatched number of cohort studies in many countries, provides new hazard ratio functions ...
Lelieveld J +6 more
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On the Interpretation of the Hazard Ratio and Communication of Survival Benefit. [PDF]
Oncologist, 2017 Sashegyi A, Ferry D.
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How Do the Accrual Pattern and Follow-Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated? [PDF]
Oncologist, 2019 In randomized clinical trials, the magnitude of the treatment effect is often reported using the hazard ratio (HR) even when the proportional hazards (PH) assumption is not met.
Horiguchi M, Hassett MJ, Uno H.
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Estimation of the 2-sample hazard ratio function using a semiparametric model [PDF]
Biostatistics, 2010 Song Yang, R. L. Prentice
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On confidence intervals for the hazard ratio in randomized clinical trials. [PDF]
Biometrics, 2016 The log‐rank test is widely used to compare two survival distributions in a randomized clinical trial, while partial likelihood (Cox, 1975) is the method of choice for making inference about the hazard ratio under the Cox (1972) proportional hazards ...
Lin DY, Dai L, Cheng G, Sailer MO.
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