Results 71 to 80 of about 6,418,358 (332)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Recurrence Rate and Associated Factors of Primary Fallopian Tube Carcinoma in the South of Vietnam

Gynecology and Minimally Invasive Therapy
Objectives: This study aimed to determine the recurrence rate and related risk factors of primary fallopian tube cancer (PFTC). Materials and Methods: We conducted a retrospective study of 47 patients with histopathological diagnosis of PFTC treated at ...
Tuan Vo, Duy Nguyen, Thang Ho, Hoang Tran, Dat Nguyen, Thuong Bui, Thinh Cao, Brian Vo   +7 more
doaj   +1 more source

Significantly Increased Risk of All-Cause Mortality Among Type 2 Diabetes Patients Living Alone

Frontiers in Medicine, 2022
BackgroundThere is a lack of studies evaluating the association between living status and subsequent outcomes in patients with type 2 diabetes (T2DM).ObjectivesThis study aimed to assess the association between living alone and the risk of all-cause ...
Liyao Fu, Liyao Fu, Ying Zhou, Ying Zhou, Jiaxing Sun, Zhenhua Xing, Yongjun Wang, Shi Tai   +7 more
doaj   +1 more source

Do good health and material circumstances protect older people from the increased risk of death after bereavement? [PDF]

, 2012
This is an open access Article. Copyright @ 2012 The AuthorsAn increased risk of death in persons who have suffered spousal bereavement has been described in many populations.
Bourke, Bowling, Boyle, Buckley, C. R. Victor, Charlson, D. G. Cook, Hart, Holmes, I. M. Carey, Lewis, Manor, Martikainen, Martikainen, Martikainen, Moon, Parkes, Phillips, S. DeWilde, S. M. Shah, Schaefer, Sloggett, Stroebe, T. Harris   +23 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Physical activity and risk of cholelithiasis: a narrative review

Frontiers in Medicine
Cholelithiasis, commonly known as gallstone disease, poses a significant public health concern globally, with a myriad of risk factors contributing to its development.
Zhen Ye, Jinkun Xie, Xiao Ni, Jiyong Yang, Jiong Li, Yujun Xuan, Honggang Gu   +6 more
doaj   +1 more source

Cryptocurrencies and Tokens Lifetime Analysis from 2009 to 2021

Economies, 2022
The success of Bitcoin has spurred emergence of countless alternative coins with some of them shutting down only few weeks after their inception, thus disappearing with millions of dollars collected from enthusiast investors through initial coin offering
Paul Gatabazi, Gaëtan Kabera, Jules Clement Mba, Edson Pindza, Sileshi Fanta Melesse   +4 more
doaj   +1 more source

What is wrong with non-respondents? Alcohol-, drug- and smoking related mortality and morbidity in a 12-year follow up study of respondents and non-respondents in the Danish Health and Morbidity Survey [PDF]

, 2015
Aim: Response rates in health surveys have diminished over the last two decades, making it difficult to obtain reliable information on health and health-related risk factors in different population groups.
Christensen, Anne Illemann, Ekholm, Ola, Glümer, Charlotte, Gray, Linsay, Juel, Knud   +4 more
core   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Education, skills, and duration of unemployment in Ghana

Cogent Economics & Finance, 2023
The unmatched growth in available jobs, given the rising youth population, is a major concern for policymakers in sub-Saharan African countries (SSAs), particularly Ghana.
Ebenezer Gyan Yirenkyi, Godwin Debrah, Kwami Adanu, Edwin Atitsogbui   +3 more
doaj   +1 more source