Results 81 to 90 of about 3,571,431 (286)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Estimate hazard ratios in small clinical trials without reported hazard ratios
Discover OncologyFor survival studies, pooling hazard ratios (HRs) across multiple clinical trials through meta-analysis is commonly performed to achieve widely accepted and robust conclusions. However, clinical trials sometimes do not report HRs.We developed a new, simple approach to estimate HRs by reconstructing life tables from Kaplan-Meier (KM) curves ...
Shuyuan Wang +3 more
openaire +3 more sources
Optimal approximate conversions of odds ratios and hazard ratios to risk ratios
Biometrics, 2020 AbstractOdds ratios approximate risk ratios when the outcome under consideration is rare but can diverge substantially from risk ratios when the outcome is common. In this paper, we derive optimal analytic conversions of odds ratios and hazard ratios to risk ratios that are minimax for the bias ratio when outcome probabilities are specified to fall in ...
openaire +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Current OncologyCanada’s decentralized healthcare system may lead to regional disparities in survival among Canadians diagnosed with central nervous system (CNS) tumours.
Yifan Wu, Emily V. Walker, Yan Yuan
doaj +1 more source
Nutritional epidemiology methods and related statistical challenges and opportunities
Statistical Theory and Related Fields, 2018 The public health importance of nutritional epidemiology research is discussed, along with methodological challenges to obtaining reliable information on dietary approaches to chronic disease prevention.
Ross L. Prentice, Ying Huang
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Recurrence Rate and Associated Factors of Primary Fallopian Tube Carcinoma in the South of Vietnam
Gynecology and Minimally Invasive TherapyObjectives: This study aimed to determine the recurrence rate and related risk factors of primary fallopian tube cancer (PFTC). Materials and Methods: We conducted a retrospective study of 47 patients with histopathological diagnosis of PFTC treated at ...
Tuan Vo +7 more
doaj +1 more source