Results 91 to 100 of about 3,571,431 (286)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Limitations of hazard ratios in clinical trials

European Heart Journal, 2018
Abstract
Mats J, Stensrud, John M, Aalen, Odd O, Aalen, Morten, Valberg   +3 more
openaire   +2 more sources

Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults

Frontiers in Endocrinology
ObjectiveThis study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults.Methods13,500 participants from the Zhejiang Adult Chronic Disease Study were followed ...
Jing-jing Lin, Pin-yuan Dai, Jie Zhang, Yun-qi Guan, Wei-wei Gong, Min Yu, Le Fang, Ru-ying Hu, Qing-fang He, Na Li, Li-xin Wang, Ming-bin Liang, Jie-ming Zhong   +12 more
doaj   +1 more source

Factors Affecting Nutritional Attitudes among University Adults [PDF]

Pakistan Journal of Commerce and Social Sciences, 2017
The problem of malnutrition has never been good and the information regarding nutrition would be advantageous particularly in case of Pakistan because significant progress of nutrition awareness at regional level is scarce.
Jamal Abdul Nasir
doaj  

Multivariate hazard orderings of discrete random vectors [PDF]

The task of comparing two random vectors with respect to some multivariate stochastic ordering usually involves an infinite number of comparisons. Dyckerhoff and Mosler (1997) proved that, when the random vectors have finite supports, this task, for some
Colangelo Antonio
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Incorrect Hazard Ratio in Figure 2. [PDF]

JAMA Oncol, 2017
europepmc   +3 more sources

Testing for the Monotone Likelihood Ratio Assumption [PDF]

Monotonicity of the likelihood ratio for conditioned densities is a common technical assumption in economic models. But we have found no empirical tests for its plausibility.
Hennessy, David A., Roosen, Jutta
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Perceived benefits and health risks of cigarette smoking among young adults: insights from a cross-sectional study

Tobacco Induced Diseases, 2015
Background Perceptions of smoking-related health risks and benefits among young adults (18–24 years) and their smoking behaviour have not been adequately studied in low-income countries like Nepal.
Umesh Raj Aryal, Dharma Nand Bhatta
doaj   +1 more source