Results 101 to 110 of about 3,571,431 (286)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Estimated hazard ratio from adjusted cox model.

, 2021
Estimated hazard ratio from adjusted cox model.
Pascal N. Tyrrell (11402057), Yee Ung (11402054), Stella Wang (11140027), Saly Abo Zahra (11402060), Hassan Alomaish (11402051), Anastasia Oikonomou (9405635)   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Survival model analysis of tuberculosis treatment among patients with human immunodeficiency virus coinfection

International Journal of Mycobacteriology, 2019
Background: Tuberculosis (TB) with human immunodeficiency virus (HIV) coinfection is the highest clinical epidemiology and public health issue. Despite many programs established to tackle the epidemic, TB target controls have not been reached. One of the
Adeboye Azeez, Ruffin Mutambayi, Akinwumi Odeyemi, James Ndege   +3 more
doaj   +1 more source

Adjusted hazard ratio according to stage and AST/ALT ratio.

, 2016
Adjusted hazard ratio according to stage and AST/ALT ratio.
Yukinori Takenaka (584373), Susumu Nakahara (584374), Toshimichi Yasui (584370), Atshushi Hanamoto (3216921), Hironori Cho (3216933), Hidenori Inohara (515935), Atsuhiko Uno (3214665), Takahito Fukusumi (3216927), Masashi Yamamoto (407190), Haruka Miyabe (3216912), Norihiko Takemoto (3216918), Takahiro Michiba (3216915), Naoki Ashida (3216924), Kotaro Shimizu (3216930), Yoshifumi Yamamoto (584371)   +14 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multivariable Survival Analyses (Cox regression and Competing risk) for hazard ratio (HR) and subdistribution hazard ratio (SHR) for death.

, 2016
Multivariable Survival Analyses (Cox regression and Competing risk) for hazard ratio (HR) and subdistribution hazard ratio (SHR) for death.
Punit Yadav (535503), Khai Ping Ng (3343097), Mark D. Jesky (535502), Melanie Calvert (89959), Indranil Dasgupta (3343091), Derek Kyte (466852), Paul Cockwell (345149), Anthony Fenton (3343094), Stephanie J. Stringer (535501), Charles J. Ferro (319168), Mary Dutton (535505)   +10 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

IMF Bailouts and Moral Hazard [PDF]

This paper empirically investigates the extent of investor moral hazard associated with IMF bailouts by analyzing the responses of sovereign bond spreads to the changes in the perceived probability of IMF bailouts of countries undergoing financial crisis.
Jong-Wha Lee, Kwanho Shin
core