Results 41 to 50 of about 7,521 (213)

Clinical Analysis of Polyethylene Glycol Interferon-α Treatment in 155 Hepatitis B e Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB) Patients

Annals of Hepatology, 2017
Purpose: This study aims to investigate the antiviral effect of polyethylene glycol (PEG)-interferon α-2a and PEG-interferon α-2b treatment on hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) at the 48th week of treatment and the 24th and
Xin Luo, Ji-Xian Yu, Lei Xie, Wen-Jun Ma, Li-Hong Wang   +4 more
doaj   +1 more source

Optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment HBV DNA: a 5-Year prospective study

Virology Journal, 2011
Background Adefovir Dipivoxil (ADV) is an important agent to suppress hepatitis B virus (HBV) replication with suboptimal effect on virological and serological response.
Zhang Jing, Shen Fei, Geng Da, Lu Hui, Lu Bing, Ma Li   +5 more
doaj   +1 more source

Potential Efficacy of Pegylated Interferon-α and a Nucleos(t)ide Analogue as Combination Therapy for HBeAg-Positive Chronic Hepatitis B

Gut and Liver, 2016
Background/AimsDespite the potent suppression of the hepatitis B virus with modern antiviral agents, only a minority of HBeAg-positive patients achieve hepatitis B e antigen seroconversion.
Chung-Il Wi, W. Ray Kim, John B. Gross, Linda M. Stadheim, John J. Poterucha   +4 more
doaj   +1 more source

Effects of dyslipidemia on E antigen seroconversion of patients with chronic hepatitis B treated by nucleoside (acid) analogs

Lipids in Health and Disease, 2021
Background The prevalence of dyslipidemia in China is increasing annually. Current studies suggest that dyslipidemia affects the antiviral efficacy of hepatitis C virus (HCV) therapies, while recent studies suggest that serum lipids influence the ...
Ziqiang Xia, Juzeng Zheng, Liang Zheng, Endian Zheng, Zhuolin Zou, Xiong Sheng, Jinming Wu   +6 more
doaj   +1 more source

NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection [PDF]

, 2017
Background Chronic HBV infection can be divided into 4 distinct clinical phases: immune tolerant, immune active, inactive carrier, and HBeAg-negative hepatitis.
Boonstra, P.A. (André), Groen, R.A. (Rik) de, Groothuismink, Z.M.A. (Zwier), Hou, J. (Jun), Knegt, R.J. (Robert) de, Oord, G.W. (Gertine) van, van der Heide, M. (Marieke)   +6 more
core   +1 more source

HBV RNA Predicts the Risk of Off‐Treatment Relapse in Chronic Hepatitis B Patients With NAs Therapy: A Systematic Review and Meta‐Analysis [PDF]

J Viral Hepat
ABSTRACT Since there are currently few antiviral drugs that can effectively reduce hepatitis B surface antigen levels, the recurrence rate remains high in patients with chronic hepatitis B (CHB) after discontinuing nucleoside analogues (NAs) treatment.
Wang D, Wang J, Jiang S, Zhou A, Jin M, Zhang H, Yang S, Fan S, Hu A.   +8 more
europepmc   +2 more sources

TCRγδ(+)CD4(-)CD8(-) T cells suppress the CD8(+) T-cell response to hepatitis B virus peptides, and are associated with viral control in chronic hepatitis B. [PDF]

PLoS ONE, 2014
The immune mechanisms underlying failure to achieve hepatitis B e antigen (HBeAg) seroconversion associated with viral control in chronic hepatitis B (CHB) remain unclear.
Qintao Lai, Shiwu Ma, Jun Ge, Zuxiong Huang, Xuan Huang, Xiaotao Jiang, Yongyin Li, Mingxia Zhang, Xiaoyong Zhang, Jian Sun, William G H Abbott, Jinlin Hou   +11 more
doaj   +1 more source

The association between maternal hepatitis B e antigen status, as a proxy for perinatal transmission, and the risk of hepatitis B e antigenaemia in Gambian children. [PDF]

, 2014
BACKGROUND: Early age at infection with hepatitis B virus (HBV) increases the risk of chronic HBV infection. In addition early age at infection may further increase the risk of persistent viral replication beyond its effect on chronicity.
Bottomley, Christian, Mendy, Maimuna, Njie, Ramou, Shimakawa, Yusuke   +3 more
core   +4 more sources

Incidence and Characteristics of HBV Reactivation‐Related Events Following HBsAg Seroclearance: Long‐Term Follow‐up of a Population‐Based Cohort in Japan

Hepatology Research, EarlyView.
In a population‐based cohort in Japan, HBV reactivation‐related events were observed after HBsAg seroclearance, including one virologically confirmed hepatic flare occurring spontaneously without chemotherapy or immunosuppression. These findings indicate that HBsAg seroclearance does not always represent complete viral eradication, supporting the need ...
Kazumi Yamasaki, Satoshi Shirahama, Takahiro Yasaka, Shota Yamaguchi, Masashi Mizokami, Junko Tanaka, Hiroaki Okamoto, Hiroshi Yatsuhashi   +7 more
wiley   +1 more source

HBsAg seroclearance in the chronic hepatitis B patients whom naïve and nucleos(t)ide analogue-treated: a long-term follow-up study

The Turkish Journal of Gastroenterology, 2019
This study was conducted in Trabzon Karadeniz Technical University Faculty of Medicine, Department of Infectious Diseases. Spontaneous HBsAg seroclearance is infrequent in adult HBV infection.
Iftihar Koksal, Bengü Pakyurek, Gurdal Yilmaz   +2 more
doaj   +1 more source