Results 81 to 90 of about 7,551 (201)

NK cell phenotypic and functional shifts coincide with specific clinical phases in the natural history of chronic HBV infection [PDF]

, 2017
Background Chronic HBV infection can be divided into 4 distinct clinical phases: immune tolerant, immune active, inactive carrier, and HBeAg-negative hepatitis.
Boonstra, P.A. (André), Groen, R.A. (Rik) de, Groothuismink, Z.M.A. (Zwier), Hou, J. (Jun), Knegt, R.J. (Robert) de, Oord, G.W. (Gertine) van, van der Heide, M. (Marieke)   +6 more
core   +1 more source

A Systematic Review and Model‐Based Meta‐Analysis of Pegylated‐Interferon‐α‐Induced HBsAg Loss in Chronic Hepatitis B Virus Infection

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pegylated‐interferon‐α (Peg‐IFNα) is a treatment option for chronic hepatitis B virus (HBV) infection. To quantify treatment response variability, we conducted a model‐based meta‐analysis (MBMA) of hepatitis B surface antigen (HBsAg) loss, defined as a binary outcome based on HBsAg levels falling below the limit of detection, with Peg‐IFNα ...
Nathan J. Hanan, Matthew L. Zierhut, Ahmed Nader, Anadi Mahajan, Amandeep Kaur, Krishna Kumar, Susan A. Dixon, Joyeta Das, Mindy Magee, Dickens Theodore, Vera Gielen   +10 more
wiley   +1 more source

Immunomodulatory Function of HBeAg Related to Short-Sighted Evolution, Transmissibility, and Clinical Manifestation of Hepatitis B Virus

Frontiers in Microbiology, 2018
Hepatitis B virus (HBV) infection, a global public health problem can be asymptomatic, acute or chronic and can lead to serious consequences of infection, including cirrhosis, and hepatocellular carcinoma.
Anna Kramvis, Evangelia-Georgia Kostaki, Angelos Hatzakis, Dimitrios Paraskevis   +3 more
doaj   +1 more source

Quantitative HBsAg and HBeAg predict hepatitis B seroconversion after initiation of HAART in HIV-HBV coinfected individuals. [PDF]

PLoS ONE, 2013
OBJECTIVE: Anti-HBe seroconversion and HBsAg loss are important therapeutic endpoints in patients with hepatitis B virus (HBV) infection. Quantitative measures of hepatitis B surface antigen (qHBsAg) and e antigen (qHBeAg) have been identified as ...
Gail V Matthews, Rachel J Ali, Anchalee Avihingsanon, Janaki Amin, Rachel Hammond, Scott Bowden, Sharon R Lewin, Joe Sasadeusz, Margaret Littlejohn, Stephen L Locarnini, Kiat Ruxrungtham, Gregory J Dore   +11 more
doaj   +1 more source

Early Viral Kinetics with Telbivudine, Tenofovir or Combination of Both in Immunotolerant Patients with Hepatitis B e Antigen-Positive Chronic Hepatitis B [PDF]

, 2014
INTRODUCTION: Viral kinetics has proved useful in understanding antiviral potency, determining antiviral profiles and optimizing treatment strategy. METHODS: This was a randomized, open-label study comparing the viral kinetics in 46 hepatitis B e antigen-
Aldo Trylesinski, Eva Herrmann, George K. K. Lau, Henry L. Y. Chan, Nancy W. Y. Leung, Nikolai V. Naoumov, Stefan Zeuzem, Tokutei M. K. So, Yu Dong   +8 more
core   +1 more source

Efficacy and Safety of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil Fumarate (TDF) Followed by TAF in Chronic Hepatitis B Patients of East Asian Ethnicity Following 5 Years of Treatment

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 1, Page 132-144, January 2026.
In East Asian patients with chronic hepatitis B, rates of virologic suppression through 5 years were high in those treated continuously with tenofovir alafenamide (TAF) and in those switched from tenofovir disoproxil fumarate (TDF) to TAF. Improved renal and bone safety was observed in patients switching from TDF to TAF.
Grace Lai‐Hung Wong, Edward Gane, Calvin Q. Pan, Scott Fung, Mang M. Ma, Namiki Izumi, Shalimar, Seng Gee Lim, Wan‐Long Chuang, Rajiv Mehta, Young‐Suk Lim, Leland J. Yee, John F. Flaherty, Frida Abramov, Hongyuan Wang, Maria Buti   +15 more
wiley   +1 more source

IL28B is associated with outcomes of chronic HBV infection [PDF]

, 2015
Purpose The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are associated with HBV outcomes.
Chi, Xiumei, Gao, Yanhang, Jiang, Jing, Li, Wanyu, Minuk, Gerald, Niu, Junqi, Pan, Yu, Shi, Xiaodong, Xu, Damo, Yang, Chen, Zhang, Manna, Zhong, Jin   +11 more
core   +1 more source

Long‐Term Follow‐Up of Patients in a Prospective Study of NA Discontinuation Identifies Different Patterns of HBsAg Loss

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 2, Page 231-241, January 2026.
We evaluated long‐term outcomes following nucleos(t)ide analogue discontinuation in HBeAg‐negative chronic hepatitis B. HBsAg loss was infrequent. Early HBsAg loss occurred in patients with low end‐of‐treatment HBsAg levels and without ALT flare, whilst late HBsAg loss typically followed ALT flares and was associated with higher end‐of‐treatment HBsAg ...
Simon J. Hume, Samuel Hall, Gareth Burns, Sara Vogrin, Daniel Tassone, Paul Desmond, Dilip Ratnam, Miriam T. Levy, Rohit Sawhney, Amanda Nicoll, Zina Valaydon, Simone I. Strasser, Meng Ngu, Marie Sinclair, Chris Meredith, Gayle V. Matthews, Kumar Visvanathan, Jacinta A. Holmes, Alexander J. Thompson   +18 more
wiley   +1 more source

HBeAg and Anti HBe Status in Patients with Chronic Hepatitis B Infection [PDF]

, 2010
Background: Data on HBeAg and anti HBe status in patients with chronic hepatitis B infection are not yet available in Indonesia. This study was done to acquire data on HBeAg and anti HBe status in patients with hepatitis B chronic infection. Method: The
Achwan, W. A. (Wenny), Gunawan, S. (Stephanus), Laksono, B. T. (Baskoro), Mahendra, K. (Ketut), Soemohardjo, S. (Soewignjo), Taufiq, H. S. (Herman), Widita, H. (Haris), Wilusanta, I. G. (I)   +7 more
core   +1 more source

Chronic Hepatitis B Virus Infection Acquired Under Cytostatic Treatment in Childhood — Clinical, Virological and Immunological Long‐Term Follow‐Up

Journal of Viral Hepatitis, Volume 33, Issue 1, January 2026.
ABSTRACT Oncology patients receiving cytostatic therapy used to be at high risk of HBV infection when HBV screening measures were less reliable. Infections acquired under these conditions often persist, like those acquired perinatally or during early infancy.
Thomas Baumgarten, Felix Lehmann, Tina Senff, Heiko Slanina, Christian G. Schüttler, Andreas Walker, Wolfram H. Gerlich, Reinald Repp, Jörg Timm, Dieter Glebe, Markus Metzler   +10 more
wiley   +1 more source