Results 31 to 40 of about 93,843 (327)

MORPHOLOGICAL ANALYSIS OF HEPATITIS B VIRUS WITH ESCAPE MUTATIONS IN S-gene G145R AND S143L

Вопросы вирусологии, 2017
Background. In terms of serological properties and immunization, the wild type of HBsAg HBV and its G145R mutant behave as different antigens. This testifies to serious structural changes, which presumably could have a significant impact on the ...
M. V. Konopleva, M. V. Sokolova, N. V. Shevlyagina, A. I. Bazhenov, A. A. Fel’Dsherova, M. A. Krymskij, V. N. Borisova, T. A. Semenenko, V. G. Nesterenko, A. P. Suslov   +9 more
doaj   +1 more source

Kan vericilerde HBsAg, anti-HCV, anti-HIV ve Sifilis seroprevalansı

Sakarya Tıp Dergisi, 2011
Bu çalışmada Afyon Kocatepe Üniversitesi Tıp Fakültesi Kan Merkezi'ne başvuran donörlerde HBsAg, anti-HCV, anti-HIV 1/2 ve RPR seroprevalansının tespiti ve oranların yıllara ve cinsiyete göre dağılımının belirlenmesi amaçlanmıştır.
Mustafa Altındiş, Raike Kalaycı, Savaş Aslan   +2 more
doaj   +1 more source

HBsAg sT123N mutation induces stronger antibody responses to HBsAg and HBcAg and accelerates in vivo HBsAg clearance

Virus Research, 2015
Immune escape mutants with mutations in the hepatitis B surface antigen (HBsAg) major hydrophilic region (MHR) often emerge in association with diagnostic failure or breakthrough of HBV infection in patients with anti-HBs antibodies. Some mutants harboring substitutions to Asn in HBsAg MHR may have an additional potential N-glycosylation site.
Li, Songxia, Zhao, Kaitao, Liu, Shuhui, Wu, Chunchen, Yao, Yongxuan, Cao, Liang, Hu, Xue, Zhou, Yuan, Wang, Yun, Pei, Rongjuan, Lu, Mengji, Chen, Xinwen   +11 more
openaire   +2 more sources

Persistence of HBsAg‐specific antibodies and immune memory two to three decades after hepatitis B vaccination in adults

Journal of Viral Hepatitis, 2019
The duration of protection after hepatitis B vaccination is not exactly known. This phase IV study evaluated antibody persistence and immune memory 20‐30 years after adult immunization with recombinant hepatitis B vaccine (HBsAg vaccine, Engerix‐B) in ...
P. van Damme, M. Dionne, G. Leroux-Roels, Olivier Van Der Meeren, E. Di Paolo, B. Salaun, Pemmaraju Surya Kiran, N. Folschweiller   +7 more
semanticscholar   +1 more source

Using the quantitative determination of HBsAg to predict the course of chronic hepatitis B in women during pregnancy and after childbirth

Журнал инфектологии, 2014
This study is based on the investigation of 31 HB V-infected women, which have observed at Botkin Infectious Hospital in 2012. Considerable variations of viral load in the course of pregnancy have been observed in the HB V cohort.
M. A. Belopolskaya, T. V. Volokobinskaya, S. L. Firsov, A. A. Yakovlev   +3 more
doaj   +1 more source

Identification by enzyme immunoassay of escape mutants S143L and G145R of hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus)

Вопросы вирусологии, 2022
Introduction. The achievement of the goal of the World Health Organization to eliminate viral hepatitis B by 2030 seems to be problematic partly due to the presence of escape mutants of its etiological agent, hepatitis B virus (HBV) (iHepadnaviridae ...
M. V. Konopleva, A. A. Feldsherova, D. A. Elgort, T. A. Tupoleva, N. A. Kokhanovskaya, V. N. Pankratova, T. A. Semenenko, A. P. Suslov   +7 more
doaj   +1 more source

Comparison of the Clinical Features of Hepatitis A between HBsAg-Positive and HBsAg-Negative Patients [PDF]

Gut and Liver, 2011
The notion that acute hepatitis A superimposed on chronic hepatitis B infection leads to a worse outcome than acute hepatitis A alone remains controversial. The aim of this study was to determine the influence of the presence of hepatitis B surface antigen (HBsAg) on the severity of acute hepatitis A.We retrospectively analyzed 449 patients ...
Geum-Youn Gwak, Joon Hyeok Lee, Sung June Eo, Kwang Min Kim, Seung Woon Paik, Kwang Cheol Koh, Byung Chul Yoo, Moon Seok Choi   +7 more
openaire   +4 more sources

Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels

Clinical and Translational Gastroenterology, 2017
Objectives:We aimed to determine the levels of alanine aminotransferase (ALT), hepatitis B virus DNA (HBV DNA), HBsAg, and a novel viral marker (hepatitis B core-related antigen (HBcrAg)); hepatitis B e antigen (HBeAg) seroconversion and drug resistance ...
Yuk‐Fai Lam, W. Seto, D. Wong, K. Cheung, J. Fung, L. Mak, J. Yuen, Chun-kong Chong, Ching‐lung Lai, M. Yuen   +9 more
semanticscholar   +1 more source

THE ROLE OF DNA-METHYLTRANSFERASES IN THE LIFE CYCLE OF HEPATITIS B VIRUS AND PATHOGENESIS OF CHRONIC HEPATITIS B

Вопросы вирусологии, 2018
Chronic hepatitis B is caused by a persistent form of hepatitis B virus, covalently closed circular DNA (cccDNA). Stability of cccDNA is associated with intracellular localization of cccDNA and formation of minichromosome, regulated by epigenetic ...
D. S. Kostyushev, A. P. Zueva, S. A. Brezgin, A. D. Lipatnikov, E. V. Volchkova, V. V. Maleyev, V. P. Chulanov   +6 more
doaj   +1 more source

Seroprevalence of Hepatitis B Virus in Pregnant Women at a Tertiary Care Hospital of Eastern India [PDF]

National Journal of Laboratory Medicine, 2016
Introduction: Hepatitis B virus is a DNA virus causing hepatitis in humans. It is thought to be responsible for chronic liver diseases in 75% of cases. Besides other routes, vertical transmission from mother to child is an important one.
Archana Sinha, Minu Sharan, S.K. Shahi
doaj   +1 more source