Results 101 to 110 of about 113,181 (243)

A Simplified Risk Assessment Tool to Predict Post Deceased Donor Liver Transplantation Outcomes: A Single, Highly Experienced Medical Center in Taiwan

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Liver transplantation (LT) is the standard treatment for end‐stage liver disease, yet the gap between the demand for organs and their availability is widening. In Taiwan, the scarcity of deceased donor organs highlights the need for optimized utilization strategies.
Jie‐Lan Jhang, Hao‐Chien Hung, Yin Lai, Jin‐Chiao Lee, Yu‐Chao Wang, Chih‐Hsien Cheng, Tsung‐Han Wu, Chen‐Fang Lee, Ting‐Jung Wu, Hong‐Shiue Chou, Kun‐Ming Chan, Wei‐Chen Lee   +11 more
wiley   +1 more source

Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao, Sijia Shen, Junjie Zhang, Ying Xu, Jing Peng, Hainv Gao, Lanjuan Li   +6 more
wiley   +1 more source

Incidence and Mortality Risks of Gastrointestinal Cancers During Working‐Age Period: Trends and Disparities in 204 Countries and Territories (1990–2021)

Med Research, EarlyView.
This comprehensive analysis of gastrointestinal (GI) cancer risk reveals that globally, one in 46 people will develop and one in 73 will die from GI cancers during working age (15–64 years), with 2021 incidence and mortality risks of 2.19% and 1.37%, respectively. Key findings demonstrate striking gender disparities, with males facing nearly double the
Yiming Song, Zhongge Ji, Xunbing Zhang, Qian Liang, Zeyu Li, Xiaojie Huang, Jinnan Chen, Yujie Zhou, Xinyuan Wang, Zhao Li, Liuyi Yang, Yixin Qian, Xiaolu Lin, Qingwei Zhang, Xiaobo Li   +14 more
wiley   +1 more source

Liver Transplantation After Combination Therapy Based on Immune Checkpoint Inhibitors: A Multicenter Retrospective Study of Safety and Efficacy

Organ Medicine, EarlyView.
This multicenter retrospective study assessed preoperative immune checkpoint inhibitor (ICI) therapy in 17 hepatocellular carcinoma patients undergoing liver transplantation. All received at least one cycle of ICI‐based combination therapy before transplant and achieved a 76.5% objective response rate.
Huanquan Chen, Tianxing Dai, Jie Gao, Chuanjiang Li, Huanwei Chen, Feiwen Deng, Nan Ma, Guoying Wang   +7 more
wiley   +1 more source

Disease Burden of Liver Cancer and Its Underlying Etiologies Globally and in China From 1990 to 2021: Results From the Global Burden of Disease Study 2021

Portal Hypertension &Cirrhosis, EarlyView.
Liver cancer remains a leading global health threat, imposing a substantial and growing burden of disease and disability. This study explores the epidemiologic landscape of liver cancer worldwide and within China over recent decade using Global Burden of Disease database 2021 study.
Jiaqi Ruan, Hangkai Huang, Chengfu Xu
wiley   +1 more source

Liver Fibrosis Tests and Outcomes of Bariatric Surgery in Morbidly Obese Patients With MASLD

Portal Hypertension &Cirrhosis, EarlyView.
This study validates commonly used non‐invasive tests for liver fibrosis in morbidly obese patients with biopsy‐proven MASLD and evaluates outcomes after bariatric surgery. These non‐invasive tests show low diagnostic accuracy for baseline liver fibrosis, while bariatric surgery significantly improves liver stiffness, metabolic profiles, and ...
Parinda Prathyajuta, Thaninee Prasoppokakorn, Kessarin Thanapirom, Pattharasai Kachornvitaya, Kanokwan Sonsiri, Chonlada Phathong, Arth Khemtong, Suthep Udomsawaengsup, Sombat Treeprasertsuk   +8 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

The Safety of Interferon‐Based Therapies in Chronic Hepatitis B Patients With Compensatory Cirrhosis

Portal Hypertension &Cirrhosis, EarlyView.
While nucleos(t)ide analog (Nuc) therapy is the standard for chronic hepatitis B, pegylated interferon‐alpha (Peg‐IFN‐α) provides unique advantages, including finite treatment duration and long‐term benefits. However, its use in patients with compensated cirrhosis remains limited due to persistent safety concerns about potential decompensation and ...
Qiran Zhang, Taoran Geng, Ruirui You, Huiling Xiang, Ying Guo, Xiaohong Gao, Guojun Li, Qun Zhang, Xiaoping Wu, Haifang Cao, Wenhua Zhang, Jia Shang, Jiawei Geng, Lihong Qu, Shuilin Sun, Xiulan Xue, Rui Zhao, Lihua Zhong, Guohong Ge, Yanbin Wang, Jianqi Lian, Ming Liang, Qing Ye, Xiaoyan Wang, Xiaoqing Guo, Dan Xu, Yiqi Yu, Feng Sun, Chao Qiu, Jiming Zhang, Yuxian Huang, Wenhong Zhang, Xiaolong Qi   +32 more
wiley   +1 more source

A Dermal Plaque on the Arm

JEADV Clinical Practice, EarlyView.
Claudine Howard‐James, Aisling Nolan, Graham Woods, Ian McDonald   +3 more
wiley   +1 more source

Diverse immunological roles of liver‐resident immune cells in liver diseases

Precision Medical Sciences, EarlyView.
Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan, Xinqiang Li, Peng Jiang, Dahong Teng, Jinzhen Cai   +4 more
wiley   +1 more source