Results 121 to 130 of about 325,525 (350)

Standardized Management Pathway to Prevent Acute Rejection After Liver Transplantation Following ICI Therapy for Downstaging HCC

Health Care Science, EarlyView.
Findings indicate that within a standardized clinical pathway integrating structured immunosuppression, therapeutic drug monitoring, and early complication surveillance, liver transplantation after ICI exposure can be performed safely without increased rejection risk.
Ning Wang, Zebin Zhu, Hao Zheng, Can Qi, Xiaodong Yuan, Xuefeng Li, Zhijun Xu, Jiwei Qin, Wei Wu, Jizhou Wang, Ruipeng Song, Zhiyong Guo, Lianxin Liu, Shu‐Geng Zhang, Björn Nashan   +14 more
wiley   +1 more source

Recent Update on the Role of Circular RNAs in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Abdullah Ely, Kristie Bloom, Mohube Betty Maepa, Patrick Arbuthnot Wits/SAMRC Antiviral Gene Therapy Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaCorrespondence: Patrick ...
Ely A, Bloom K, Maepa MB, Arbuthnot P
doaj  

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon.

Gastroenterology, 2018
BACKGROUND & AIMS Hepatitis C virus (HCV) infection is sensitive to interferon (IFN)-based therapy, whereas hepatitis B virus (HBV) infection is not. It is unclear whether HBV escapes detection by the IFN-mediated immune response or actively suppresses ...
P. Mutz, P. Metz, Florian A. Lempp, S. Bender, B. Qu, K. Schöneweis, S. Seitz, T. Tu, A. Restuccia, J. Frankish, Christopher Dächert, B. Schusser, R. Koschny, G. Polychronidis, P. Schemmer, K. Hoffmann, T. Baumert, M. Binder, S. Urban, R. Bartenschlager   +19 more
semanticscholar   +1 more source

Designing a therapeutic hepatitis B vaccine to circumvent immune tolerance

Human Vaccines & Immunotherapeutics, 2020
An effective prophylactic hepatitis B virus (HBV) vaccine has long been available but is ineffective for chronic infection. The primary cause of chronic hepatitis B (CHB) and greatest impediment for a therapeutic vaccine is the direct and indirect ...
DC Whitacre, CJ Peters, C Sureau, K Nio, F Li, L Su, JE Jones, M Isogawa, M Sallberg, L Frelin, DL Peterson, DR Milich   +11 more
doaj   +1 more source

Strategies for hepatitis B booster vaccination among children: an 8-year prospective cohort study

Human Vaccines & Immunotherapeutics, 2020
Debate continues regarding the need for a booster vaccination in children who received a universal infant hepatitis B virus (HBV) vaccination. The aim was to explore the need and the strategies for the booster HBV vaccination.
Yan Qiu, Jing-Jing Ren, Zi-Kang Wu, Ling-Zhi Shen, Huan Shan, Xue-Wei Dai, Jing Li, Ying Liu, Wen Ren, Jun Yao, Lan-Juan Li   +10 more
doaj   +1 more source

Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx–DDB1 Interaction

Cellular and Molecular Gastroenterology and Hepatology, 2018
Background & Aims Hepatitis B virus (HBV) infection is a major health concern worldwide. Although currently used nucleos(t)ide analogs efficiently inhibit viral replication, viral proteins transcribed from the episomal viral covalently closed circular ...
Kazuma Sekiba, M. Otsuka, M. Ohno, M. Yamagami, T. Kishikawa, Tatsunori Suzuki, Rei Ishibashi, Takahiro Seimiya, Eri Tanaka, K. Koike   +9 more
semanticscholar   +1 more source

Immune response to vaccines in children with celiac disease [PDF]

, 2017
Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and ...
ANANIA, Caterina, CHIESA, CLAUDIO, OLIVERO, FRANCESCA, PACIFICO, Lucia, Spagnolo, Alessandra   +4 more
core   +1 more source

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

PLoS ONE, 2017
The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing HBV X protein (HBx), which targets Smc5/6 for degradation.
C. Niu, Christine M. Livingston, Li Li, R. Beran, S. Daffis, D. Ramakrishnan, Dara L Burdette, Leanne Peiser, E. Salas, Hilario J Ramos, Mei Yu, G. Cheng, M. Strubin, William E Delaney Iv, S. Fletcher   +14 more
semanticscholar   +1 more source

Prevalence of HIV and Its Co-Infection with Hepatitis B/C Virus Among Chronic Liver Disease Patients in Ethiopia

Hepatic Medicine: Evidence and Research, 2022
Yayehyirad Tassachew,1– 3 Tamrat Abebe,1 Yeshambel Belyhun,4 Tezazu Teffera,5 Abate Bane Shewaye,6,7 Hailemichael Desalegn,8 Henok Andualem,9 Abiy Kinfu,10 Andargachew Mulu,2 Adane Mihret,1,2 Rawleigh Howe,2 Abraham Aseffa2 1Department of Microbiology ...
Tassachew Y, Abebe T, Belyhun Y, Teffera T, Shewaye AB, Desalegn H, Andualem H, Kinfu A, Mulu A, Mihret A, Howe R, Aseffa A   +11 more
doaj  

Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

Nature Communications, 2016
Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in ...
Ling-hao Zhao, Xiao Liu, Hexin Yan, Weiyang Li, Xi Zeng, Yuan Yang, Jie Zhao, Shiping Liu, X. Zhuang, Chuan Lin, Chen-Jie Qin, Yi Zhao, Z. Pan, Gang Huang, Hui Liu, Jin Zhang, Ruo-yu Wang, Yun Yang, Wen Wen, Guishuai Lv, Hui‐Lu Zhang, Han Wu, Shuai Huang, Ming-Da Wang, L. Tang, H. Cao, Ling Wang, Tin-Lap Lee, Hui Jiang, Ye-Xiong Tan, S. Yuan, Guo‐jun Hou, Qi‐fei Tao, Qing‐guo Xu, Xiuqing Zhang, Meng-chao Wu, Xun Xu, Jun Wang, Huan-Ming Yang, Weiping Zhou, Hong-Yang Wang   +40 more
semanticscholar   +1 more source