Results 161 to 170 of about 173,141 (216)

The role of HBV-induced autophagy in HBV replication and HBV related-HCC

Life Sciences, 2018
Hepatitis B virus (HBV) is infecting about 364 million people around the world. It can cause various diseases, such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). However, the present anti-viral treatment in clinics is limited; studies for new therapies are highly desired.
Mingjie Xie, Zhenggang Yang, Yanning Liu, Min Zheng   +3 more
openaire   +2 more sources

HBV vaccination and HBV infection induces HBV-specific natural killer cell memory

Gut, 2020
Objective Vaccination against hepatitis B virus (HBV) confers protection from subsequent infection through immunological memory that is traditionally considered the domain of the adaptive immune system. This view has been challenged following the identification of antigen-specific memory natural killer cells ...
Ratna S Wijaya, Scott A Read, Naomi R Truong, Shuanglin Han, Dishen Chen, Haleh Shahidipour, Nicole L Fewings, Stephen Schibeci, Mahmoud K Azardaryany, Grant P Parnell, David Booth, David van der Poorten, Rita Lin, Jacob George, Mark W Douglas, Golo Ahlenstiel   +15 more
openaire   +3 more sources

Interpretation of HBV Serologies

Clinics in Liver Disease, 2021
Hepatitis B was discovered by researchers who were investigating jaundice associated with blood transfusions as well as parenterally administered medications. Through trial and error, the HBV was identified. There are specific tests that detect HBV infection, whether it is a previous exposure or active infection. The various HBV serologies are reviewed
Philippe J, Zamor, Ashley M, Lane
openaire   +2 more sources

A comprehensive HBV array for the detection of HBV mutants and genotype

Clinical Biochemistry, 2011
To develop a comprehensive hepatitis B virus (HBV) array providing simultaneous analysis of 8 genotypes, 47 mutations of reverse-transcriptase polymerase gene and 18 mutations of S gene.Oligonucleotides corresponding to various HBV-normal and -mutant sequences were spotted onto pre-treated glass slides.
Alexander, GJ, Yam, I, Chan, K, Lai, CL, Yuen, MF, Chan, V, Chan, TK, Yuen, J   +7 more
openaire   +4 more sources

Treatment options in HBV

Journal of Hepatology, 2006
The available evidence on interferon-alpha (IFN) treatment for chronic hepatitis B is sufficient to conclude that in patients with HBeAg positive chronic hepatitis, standard IFN therapy significantly improves clearance of HBeAg (number needed to treat [NNT] = 4), loss of HBV-DNA (NNT = 4) and clearance of HBsAg (NNT = 18).
CRAXI, Antonio, ANTONUCCI G, CAMMA', Calogero   +2 more
openaire   +3 more sources

Mechanism of HBV genome variability and replication of HBV mutants

Journal of Clinical Virology, 2005
Naturally occurring mutations in the H13V genome have been extensively documented, yet the biological consequences of even the dominant mutations have not been well characterized. In a recent study of HBeAg-positive French patients infected with genotype A, we obtained full-length clones with high or low replication capacities in the transfected human ...
openaire   +2 more sources

A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA

Journal of Gastroenterology
Currently, standard treatments for chronic hepatitis B such as nucleos(t)ide analogs (NAs), effectively reduce hepatitis B virus (HBV) loads but rarely result in a functional cure (defined as sustained HBsAg loss). We report the discovery of a novel, 4-pyridone compound, SAG-524, a potent and orally bioavailable small molecule inhibitor of HBV ...
Takehisa Watanabe, Sanae Hayashi, Yan Zhaoyu, Hiroki Inada, Katsuya Nagaoka, Masakuni Tateyama, Yasuhito Tanaka   +6 more
openaire   +2 more sources

Immunopathogenesis of HBV Infection

2019
More than 95% of adult infected with HBV show acute self-limited infection and eventually eliminate the virus. In contrast, about 90% of people exposed to HBV in early childhood develop chronic infection. The specificity of the virus and the host's antiviral immune responses together determine the outcome of HBV infection. It is generally believed that
Jun, Wu, Meihong, Han, Jia, Li, Xiaoli, Yang, Dongliang, Yang   +4 more
openaire   +2 more sources