Results 11 to 20 of about 342,150 (384)

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF

Gut, 2021
Objective Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) pathophysiology remains unclear. This study aims to characterise the molecular basis of HBV-ACLF using transcriptomics.
Jiang Li, Xi Liang, Jing Jiang, Lingling Yang, J. Xin, D. Shi, Yingyan Lu, Jun Li, Keke Ren, H. M. Hassan, Jianing Zhang, Pengcheng Chen, Heng Yao, Jiaqi Li, Tianzhou Wu, Linfeng Jin, P. Ye, Tan Li, Huafen Zhang, Suwan Sun, Beibei Guo, Xingping Zhou, Qun Cai, Jiaxian Chen, Xiaowei Xu, Jianrong Huang, S. Hao, Jinqiu He, S. Xin, Di Wang, J. Trebicka, Xin Chen, Jun Li   +32 more
semanticscholar   +1 more source

Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis

Journal of experimental & clinical cancer research : CR, 2021
Background Hepatitis B virus (HBV) infection is a crucial risk factor for hepatocellular carcinoma (HCC). However, its underlying mechanism remains understudied.
Wenbiao Chen, Jingjing Jiang, L. Gong, Zheyue Shu, Dai-rong Xiang, Xujun Zhang, Kefan Bi, Hongyan Diao   +7 more
semanticscholar   +1 more source

HBV-Integration Studies in the Clinic: Role in the Natural History of Infection

Viruses, 2021
Hepatitis B virus (HBV) infection is a major global health problem causing acute and chronic liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV covalently closed circular DNA (cccDNA) is essential for viral replication
T. Pollicino, G. Caminiti
semanticscholar   +1 more source

The Mechanisms of HBV-Induced Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, 2021
Hepatocellular carcinoma (HCC) is a common malignancy, and the hepatitis B virus (HBV) is its major pathogenic factor. Over the past decades, it has been confirmed that HBV infection could promote disease progression through a variety of mechanisms ...
Yu Jiang, Qiuju Han, Huajun Zhao, Jian Zhang   +3 more
semanticscholar   +1 more source

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

eLife, 2021
The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system.
E. de Crignis, T. Hossain, Shahla Romal, F. Carofiglio, P. Moulos, M. Khalid, Shringar Rao, A. Bazrafshan, M. Verstegen, F. Pourfarzad, Christina Koutsothanassis, H. Gehart, T. Kan, Robert-Jan Palstra, C. Boucher, Jan Mn IJzermans, Meritxell Huch, S. Boj, R. Vries, H. Clevers, Luc J. W. van der Laan, P. Hatzis, T. Mahmoudi   +22 more
semanticscholar   +1 more source

Immunotherapy of HBV-related advanced hepatocellular carcinoma with short-term HBV-specific TCR expressed T cells: results of dose escalation, phase I trial

Hepatology International, 2021
Immunotherapy with hepatitis B virus (HBV)-specific TCR redirected T (HBV-TCR-T) cells in HBV-related hepatocellular carcinoma (HBV-HCC) patients after liver transplantation was reported to be safe and had potential therapeutic efficacy.
F. Meng, Jinfang Zhao, A. Tan, Wei Hu, Si-yu Wang, Jiehua Jin, Juan Wu, Yuan-yuan Li, Lei Shi, Jun‐liang Fu, Shuang-jie Yu, Yingjuan Shen, Liming Liu, J. Luan, M. Shi, Yunbo Xie, Chun-Bao Zhou, R. Wong, Wai Lu-En, S. Koh, A. Bertoletti, Tingting Wang, Jiyuan Zhang, Fu-Sheng Wang   +23 more
semanticscholar   +1 more source

Cytokines and Chemokines in HBV Infection

Frontiers in Molecular Biosciences, 2021
Chronic hepatitis B virus (HBV) infection remains a leading cause of hepatic inflammation and damage. The pathogenesis of chronic hepatitis B (CHB) infection is predominantly mediated by persistent intrahepatic immunopathology.
S. Zhong, Tian-ling Zhang, Libo Tang, Yongyin Li   +3 more
semanticscholar   +1 more source

Occult HBV infection [PDF]

Seminars in Immunopathology, 2012
The long-lasting persistence of hepatitis B virus (HBV) genomes in the liver (with detectable or undetectable HBV DNA in the serum) of individuals testing negative for the HBV surface antigen (HBsAg) is termed occult HBV infection (OBI). Although in a minority of cases the lack of HBsAg detection is due to infection with variant viruses unrecognized by
RAIMONDO, Giovanni, Caccamo, Gaia, FILOMIA, ROBERTO, POLLICINO, Teresa   +3 more
openaire   +2 more sources

Reactivation of hepatitis B virus with immune-escape mutations after ocrelizumab treatment for multiple sclerosis [PDF]

, 2019
Ocrelizumab is an anti-CD20 monoclonal antibody for the treatment of multiple sclerosis (MS) that is closely related to rituximab. We describe a case of hepatitis B virus (HBV) reactivation in an MS patient with resolved HBV infection receiving ...
Altieri, Marta, Annecca, Rosanna, Aragri, Marianna, Ciardi, Maria R, Iannetta, Marco, Mastroianni, Claudio M, Pontecorvo, Simona, Russo, Gianluca, Salpini, Romina, Svicher, Valentina, Vullo, Vincenzo, Zingaropoli, Maria A   +11 more
core   +1 more source

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection.

Gastroenterology, 2020
BACKGROUND & AIMS Chronic hepatitis B virus (HBV) infection is characterized by the presence of defective viral envelope proteins (hepatitis B surface antigen, HBsAg) and the duration of infection-most patients acquire the infection at birth or during ...
N. Le Bert, U. Gill, Michelle Hong, Kamini Kunasegaran, D. Tan, Raidah Ahmad, Yang Cheng, C. Dutertre, Andreas Heinecke, L. Rivino, A. Tan, Navjyot K. Hansi, Min Zhang, Sujuan Xi, Yutian Chong, Stefan Pflanz, Evan W. Newell, Patrick T F Kennedy, A. Bertoletti   +18 more
semanticscholar   +1 more source