Results 41 to 50 of about 116,974 (264)

The role of hepatitis B vaccine challenge dose in patients with underlying health conditions

Human Vaccines & Immunotherapeutics, 2021
We have evaluated the immunological response to Hepatitis B virus (HBV) booster vaccine dose in 129 adults with underlying diseases in comparison with 694 subjects at occupational risk of infection, who have previously completed the primary series and ...
L. Sticchi, I. G. Iavarone, P. Durando, A. Di Biagio, I. Schiavetti, F. Murgia, G. Icardi   +6 more
doaj   +1 more source

Hydrologic alteration and potential ecosystemic implications under a changing climate in the Chitral River, Hindukush region, Pakistan

Journal of Water and Climate Change, 2021
This study investigates changes in the hydrologic regime of the Chitral River, Hindukush–Karakoram–Himalayan (HKH) region, Pakistan. Different statistically based methods were used to assess climate change-induced hydrologic alterations that can possibly
M. Usman, X. Pan, D. Penna, B. Ahmad
doaj   +1 more source

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Glycyrrhizin preparations in liver diseases: a narrative review of mechanisms and therapeutic potential

Frontiers in Pharmacology
Glycyrrhizin preparations (GLPS), derived from Glycyrrhiza uralensis (licorice), are widely used hepatoprotective agents in clinical practice. Their primary active components, 18α- and 18β-glycyrrhetinic acid (GA), are represented by formulations ...
Tianyu Ma, Tianyu Ma, Hongxiao Hao, Hongxiao Hao, Shuojie Wang, Shuojie Wang, Dianya Qiu, Dianya Qiu, Weihua Cao, Weihua Cao, Wen Deng, Wen Deng, Shiyu Wang, Shiyu Wang, Xinxin Li, Xinxin Li, Ziyu Zhang, Ziyu Zhang, Xin Wei, Xin Wei, Linmei Yao, Linmei Yao, Zixuan Gao, Zixuan Gao, Wei Yi, Ruyu Liu, Ruyu Liu, Minghui Li, Minghui Li, Minghui Li   +29 more
doaj   +1 more source

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

Anti-HBV effect of TAT- HBV targeted ribonuclease

World Journal of Gastroenterology, 2003
To prepare and purify TAT-HBV targeted ribonuclease fusion protein, evaluate its transduction activity and investigate its effect on HBV replication in 2.2.15 cells.The prokaryotic expression vector pTAT containing TR gene was used in transforming E.coli BL21 (DE3) LysS and TR was expressed with the induction of IPTG.
Jin, Ding, Jun, Liu, Cai-Fang, Xue, Wei-Dong, Gong, Ying-Hui, Li, Ya, Zhao   +5 more
openaire   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Molecular diagnosis of the human immunodeficiency, Hepatitis B and C viruses among blood donors in Lomé (Togo) by multiplex real time PCR

The Pan African Medical Journal, 2016
This study aimed to compare the sensitivity of multiplex PCR to ELISA technique in the instantaneous detection of HBV, HCV and HIVin blood samples from donors of the National blood Transfusion Centre in Togo.
Maleki Assih, Lochina Feteke, Cyrille Bisseye, Djeneba Ouermi, Florencia Djigma, Simplice Damintoti Karou, Jacques Simpore   +6 more
doaj   +1 more source

Exosomes in HBV infection

Clinica Chimica Acta, 2023
Exosomes have been identified as important mediators of intercellular communication in several physiological and pathological processes. Hepatitis B is caused by infection with the hepatitis B virus (HBV), which impairs hepatocytes, with chronic infection resulting in cirrhosis or liver cancer.
Ziyu, Liu, Yanan, Li, Yufeng, Wang, Xinquan, Bai, Ying, Zhang   +4 more
openaire   +2 more sources

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source