TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
THE ENTROPIES OF THE SEQUENCES OF FUZZY SETS AND THE APPLICATIONS OF ENTROPY TO CARDIOGRAPHY [PDF]
In this paper, rstly we have introduced to entropy of sequences of fuzzy sets and given sometheorems about it. Secondly, the waves P and T which appears in electrocardiograms weretransferred to fuzzy sets, by using denition of entropy for sequences of ...
M. şengönül +3 more
doaj
52-week efficacy and safety of telbivudine with conditional tenofovir intensification at week 24 in HBeAg-positive chronic Hepatitis B [PDF]
Background and Aims: The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response.
Tawesak Tanwandee (279135) +50 more
core +2 more sources
Background. Hepatitis B virus (HBV) infection remains one of the neglected infectious diseases. Children infected with HBV are at higher risk of becoming chronic carriers.
Rebecca A. Mpangah +5 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Seroepidemiology of hepatitis B virus in Addis Ababa Ethiopia: transmission patterns and vaccine control [PDF]
A community-based seroepidemiological survey of Addis Ababa, Ethiopia was conducted in 1994 to inform on the transmission dynamics and control of hepatitis B virus (HBV) infection.
Cutts, FT +11 more
core +1 more source
Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas [PDF]
This paper uses meta-analysis of published data and a deterministic mathematical model of hepatitis B virus (HBV) transmission to describe the patterns of HBV infection in high endemicity areas.
Edmunds, W. John +5 more
core +1 more source
How infectious diseases arrived in the colonial Americas
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
Ville N Pimenoff, Charlotte J Houldcroft
doaj +1 more source
Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. [PDF]
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation.
Cheng, Y +59 more
core +1 more source
Role of tenofovir and telbivudine in treatment of hepatitis B related acute on chronic liver failure
Introduction: ACLF is characterized by acute deterioration of liver function in patients with chronic liver disease. HBV is one of the most important causes of both acute insult and underlying chronic liver disease in ACLF.
Debraj Malakar +9 more
doaj +1 more source

