Results 31 to 40 of about 155,598 (315)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Seroepidemiology of hepatitis B virus in Addis Ababa Ethiopia: transmission patterns and vaccine control [PDF]

, 2003
A community-based seroepidemiological survey of Addis Ababa, Ethiopia was conducted in 1994 to inform on the transmission dynamics and control of hepatitis B virus (HBV) infection.
Cutts, FT, Dejene, A, Cutts, Felicity, Nokes, D. James, Dejene, A., Messele, T., Enquselassie, F., Abebe, A, Nokes, DJ, Messele, T, Abebe, A., Enquselassie, F   +11 more
core   +1 more source

HBV Reactivation in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Narrative Review

Viruses, 2019
HBV reactivation (HBVr) can occur due to the ability of HBV to remain latent in the liver as covalently closed circular DNA and by the capacity of HBV to alter the immune system of the infected individuals.
Giuseppe Gentile, Guido Antonelli
doaj   +1 more source

SOX2 Represses Hepatitis B Virus Replication by Binding to the Viral EnhII/Cp and Inhibiting the Promoter Activation

Viruses, 2020
Hepatitis B virus (HBV) replication is controlled by four promoters (preS1, preS2, Cp, and Xp) and two enhancers (EnhI and EnhII). EnhII stimulates Cp activity to regulate the transcriptions of precore, core, polymerase, and pregenomic RNAs, and ...
Hua Yang, Jiayin Mo, Qi Xiang, Peiyi Zhao, Yunting Song, Ge Yang, Kailang Wu, Yingle Liu, Weiyong Liu, Jianguo Wu   +9 more
doaj   +1 more source

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +1 more source

Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas [PDF]

, 1996
This paper uses meta-analysis of published data and a deterministic mathematical model of hepatitis B virus (HBV) transmission to describe the patterns of HBV infection in high endemicity areas.
Edmunds, W. John, O'Callaghan, C. J., Medley, Graham, Nokes, D. James, Whittle, H. C., Hall, A. J. (Andrew James)   +5 more
core   +1 more source

52-week efficacy and safety of telbivudine with conditional tenofovir intensification at week 24 in HBeAg-positive chronic Hepatitis B [PDF]

, 2013
Background and Aims: The Roadmap concept is a therapeutic framework in chronic hepatitis B for the intensification of nucleoside analogue monotherapy based on early virologic response.
Tawesak Tanwandee (279135), Jorge Daruich, Wattana Sukeepaisarnjaroen, Rashidkhan Pathan, Eduardo Fassio, Fernando Bessone (254729), Suzane K Ono, Daruich, Jorge, Pessôa, Mário Guimarães, Yuhong Dong, Tanwandee, Tawesak, Rashidkhan Pathan (279143), Sukeepaisarnjaroen, Wattana, Mário G Pessôa, Ono, Suzane K., Teerha Piratvisuth (279131), Piyawat Komolmit (279133), Chan, Henry L. Y., Henry L Y Chan, Dong, Yuhong, Piratvisuth, Teerha, Pessôa, Mário G., Mário G. Pessôa (279138), Stefan Zeuzem (22856), Hugo Cheinquer (279142), Stefan Zeuzem, Trylesinski, Aldo, Pathan, Rashidkhan, Bessone, Fernando, Suzane K. Ono (279140), Henry L. Y. Chan (279137), Aldo Trylesinski (279145), Fassio, Eduardo, Piyawat Komolmit, Henry L. Y. Chan, Ono, Suzane Kioko, Komolmit, Piyawat, Jorge Daruich (279141), Hugo Cheinquer, Eduardo Fassio (279139), Cheinquer, Hugo, Chan, Henry, Tawesak Tanwandee, Mário G. Pessôa, Aldo Trylesinski, Suzane K. Ono, Teerha Piratvisuth, Fernando Bessone, Wattana Sukeepaisarnjaroen (279136), Yuhong Dong (279144), Zeuzem, Stefan   +50 more
core   +1 more source

HBV Immunomics 10X data

, 2023
<p>Here, we established a single-cell RNA-sequencing (scRNA-seq) dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immune response in CHB.
François Habersetzer, Thomas F. Baumert, Tobias Nilsson, Nadege Pelletier, Antonio Saviano, Marianne Forkel, Tony Kam-Thong, Klas Hatje, Nadine Kumpesa, Pauline Simo-Noumbissie, Nicolas Giroud   +10 more
core   +1 more source

Following up and re-entry of HBV reactive blood donors in Yantai area

Zhongguo shuxue zazhi, 2023
Objective To analyze the preliminary screening and follow-up testing data of HBV in Yantai area, and discuss the rationality of following up and re-entry program of HBV reactive blood donors.
Hewei SONG, Xintang SHEN, Wei WANG, Minghua XU   +3 more
doaj   +1 more source

Anti-HBV effect of TAT- HBV targeted ribonuclease

World Journal of Gastroenterology, 2003
To prepare and purify TAT-HBV targeted ribonuclease fusion protein, evaluate its transduction activity and investigate its effect on HBV replication in 2.2.15 cells.The prokaryotic expression vector pTAT containing TR gene was used in transforming E.coli BL21 (DE3) LysS and TR was expressed with the induction of IPTG.
Jin, Ding, Jun, Liu, Cai-Fang, Xue, Wei-Dong, Gong, Ying-Hui, Li, Ya, Zhao   +5 more
openaire   +2 more sources